Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

  • Review by a qualified doctor
  • Including prescription
  • Next-day delivery included


Mysimba is a prescription weight-loss treatment that works by reducing your appetite. It is available to those with a BMI of 30 or more, or to those with a BMI of 27 and over and have medical complications exacerbated by their weight. This medication should be taken in combination with a low-calorie diet and regular exercise to ensure treatment success.

How it works

Mysimba contains two active ingredients, 8 mg of naltrexone and 90 mg of bupropion. The combination of the two alters the way the brain interprets hunger by reducing your appetite and increasing your energy expenditure. This means you can maintain a low-calorie diet without feeling cravings or hunger pains and the food you do eat is burnt off more easily during exercise. This is why it’s important to use this medication alongside a healthy diet and exercise plan.

Who can take Mysimba

You can only be prescribed this medication if you are 18 or over and have a BMI of 30 and above, or 27 and above if you have other medical conditions exacerbated by your weight such as diabetes, high blood pressure or high cholesterol.

You should not take this medication if you are pregnant or breastfeeding, or are allergic to any of the ingredients.This medication is also not recommended for those over the age of 75.

If you have any of the following preexisting conditions or take any of the following medication, you should also not take Mysimba:

  • severe liver or kidney disease
  • a brain tumour
  • a condition that causes seizures (e.g epilepsy)
  • uncontrolled high blood pressure
  • a recent history of alcohol dependence or misuse
  • a recent history of taking sedatives (benzodiazepines) for a mental health disorder
  • a recent history of eating disorders (e.g anorexia)
  • a recent history of opiate dependence or have taken opiates in the last 7 days (e.g methadone or codeine)
  • take or have taken in the last 14 days any MAOIs (monoamine oxidase inhibitors) for depression or Parkinson’s disease

How to use

A full description of how to take Mysimba is available in the patient information leaflet, available at the bottom of this page or in the box with your medication. It’s important to follow these instructions to ensure treatment success.

The initial dosage of Mysimba is one tablet once a day. This is then steadily increased throughout the first weeks of treatment. The maximum recommended daily dose of Mysimba is two tablets twice a day.

Instructions are as follows:

A course of treatment usually lasts 16 weeks, after which, one of our doctors will assess your progress. If you have not lost at least 5% of your starting weight after you have finished the first course, then it’s recommended that you discontinue treatment and seek other help.

Swallow the tablets whole, do not crush, split or break them. Avoid taking your evening dose close to bedtime. Avoid excessive alcohol consumption whilst taking Mysimba, as this is more likely to cause side effects.

If you miss a dose of Mysimba, skip the missed dose and take your next dose at your usual time. If you take more than your prescribed dose, you may be more likely to experience side effects.

Side effects

Common side effects of Mysimba include:

Mysimba can cause more serious side effects such as fits (seizures) or severe depression. If you experience any serious side effects, please seek immediate medical attention.

For a full list of potential side effects, consult the patient information leaflet.


Some medications may increase the risk of fits if taken alongside Mysimba including:

Other medications may interact with Mysimba and cause other side effects including medications for:

Not all medications for these conditions will interact with Mysimba. For a comprehensive list of drug interactions, please refer to the patient information leaflet. If you’re not sure if you take any of these medications, please consult your GP before taking Mysimba.


Overview Weight loss tabletsWeight loss injectionWeight loss tablets
  Active ingredient(s)
Active ingredient(s) OrlistatLiraglutideNaltrexone & bupropion
  Who can take it
Who can take it BMI over 30 (or 27)BMI over 30 (or 27)BMI over 30 (or 27)
Features Reduces dietary fat absorption Reduces appetite Reduces appetite & increases energy expenditure
Breastfeeding UnsuitableUnsuitableUnsuitable
Pregnant Not recommendedUnsuitableNot recommended
Application TabletInjectionTablet
  How to take
How to take 3 daily tabletsDaily injectionDaily tablet(s)
Price £79.99£74.99£134.99
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Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

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As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.


If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

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All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

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There are two ways to subscribe. The first is during the order process. The second is via your profile here.

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