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Weight Loss | Active ingredient(s): Naltrexone & Bupropion | Manufacturer: OREXIGEN

Week 1- one tablet daily
Week 2 - two tablets daily
Week 3 - three tablets daily
Week 4 and beyond - four tablets daily

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  • Review by a qualified doctor
  • Including prescription
  • Next-day delivery included


Mysimba is a prescription weight-loss treatment that works by reducing your appetite. It is available to those with a BMI of 30 or more, or to those with a BMI of 27 and over and have medical complications exacerbated by their weight. This medication should be taken in combination with a low-calorie diet and regular exercise to ensure treatment success.

How it works

Mysimba contains two active ingredients, 8 mg of naltrexone and 90 mg of bupropion. The combination of the two alters the way the brain interprets hunger by reducing your appetite and increasing your energy expenditure. This means you can maintain a low-calorie diet without feeling cravings or hunger pains and the food you do eat is burnt off more easily during exercise. This is why it’s important to use this medication alongside a healthy diet and exercise plan.

Who can take Mysimba

You can only be prescribed this medication if you are 18 or over and have a BMI of 30 and above, or 27 and above if you have other medical conditions exacerbated by your weight such as diabetes, high blood pressure or high cholesterol.

You should not take this medication if you are pregnant or breastfeeding, or are allergic to any of the ingredients.This medication is also not recommended for those over the age of 75.

If you have any of the following preexisting conditions or take any of the following medication, you should also not take Mysimba:

  • severe liver or kidney disease
  • a brain tumour
  • a condition that causes seizures (e.g epilepsy)
  • uncontrolled high blood pressure
  • a recent history of alcohol dependence or misuse
  • a recent history of taking sedatives (benzodiazepines) for a mental health disorder
  • a recent history of eating disorders (e.g anorexia)
  • a recent history of opiate dependence or have taken opiates in the last 7 days (e.g methadone or codeine)
  • take or have taken in the last 14 days any MAOIs (monoamine oxidase inhibitors) for depression or Parkinson’s disease

How to use

A full description of how to take Mysimba is available in the patient information leaflet, available at the bottom of this page or in the box with your medication. It’s important to follow these instructions to ensure treatment success.

The initial dosage of Mysimba is one tablet once a day. This is then steadily increased throughout the first weeks of treatment. The maximum recommended daily dose of Mysimba is two tablets twice a day.

Instructions are as follows:

A course of treatment usually lasts 16 weeks, after which, one of our doctors will assess your progress. If you have not lost at least 5% of your starting weight after you have finished the first course, then it’s recommended that you discontinue treatment and seek other help.

Swallow the tablets whole, do not crush, split or break them. Avoid taking your evening dose close to bedtime. Avoid excessive alcohol consumption whilst taking Mysimba, as this is more likely to cause side effects.

If you miss a dose of Mysimba, skip the missed dose and take your next dose at your usual time. If you take more than your prescribed dose, you may be more likely to experience side effects.

Side effects

Common side effects of Mysimba include:

Mysimba can cause more serious side effects such as fits (seizures) or severe depression. If you experience any serious side effects, please seek immediate medical attention.

For a full list of potential side effects, consult the patient information leaflet.


Some medications may increase the risk of fits if taken alongside Mysimba including:

Other medications may interact with Mysimba and cause other side effects including medications for:

Not all medications for these conditions will interact with Mysimba. For a comprehensive list of drug interactions, please refer to the patient information leaflet. If you’re not sure if you take any of these medications, please consult your GP before taking Mysimba.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.


What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
Is the price all-inclusive?
Can I place more than one order at a time?
What are my delivery options?
Is it safe to buy prescription medication online?
How do I know which treatment is best for me?
Is this service discreet?
What is included in the online consultation?

Our consultations include general questions about your health (e.g. blood pressure levels, current and past conditions), as well as specific questions related to your selected treatment. We will also request relevant personal information to complete payment and delivery.

All questions are necessary, and your answers and details will not be shared with any third-parties. Only our doctors have access to your medical information.

Will a doctor review my consultation?

It is a legal and medical requirement that a doctor first reviews all completed consultations. We have a team of in-house doctors and specialists who will ensure your selected treatment is safe for your use. All information is stored securely and confidentially.

Please note, we do not guarantee that our doctors will approve treatment.

What happens after I submit my order?

Your consultation will be sent directly to our medical team, where it will be reviewed by one of our doctors.

If your chosen treatment is deemed suitable for your use, they will issue a prescription. Your prescription is then forwarded to our pharmacy, where your medication will be dispensed and dispatched for courier delivery.

Is the price all-inclusive?

Yes. All 121doc orders include a medical consultation, a prescription and next-day delivery. There are no additional costs. We believe in providing a safe and easy-to-use service.

Can I place more than one order at a time?

Yes. However, certain medications may negatively interact with each other. Our doctors may not approve your order on this basis.

You can place multiple items in one basket, and complete a consultation for all.

If you wish to place a second order for a different medication, you will have to complete a separate consultation.

What are my delivery options?

We offer several delivery options:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not available, a friend or relative can sign in your place.

None of these options will incur an additional charge.

Is it safe to buy prescription medication online?

To ensure you are purchasing from a reputable company, you should look to see their country’s regulatory bodies verify them.

In the UK, this is the Care Quality Commission (CQC) and the Medicines and Healthcare products Regulatory Agency (MHRA).Certificates can be viewed here.

How do I know which treatment is best for me?

Some treatments also offer the 'Advise Me' function. You will be asked questions about your lifestyle and needs, plus medical questions. You will then be presented with the advice of our doctors.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also regularly inspected by various UK regulatory agencies, such as the Information Commissioner's Office (ICO).

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.


  Pack contains 84 Xenical® 120mg Orlistat oral hard capsulesBox containing 5 pre-filled pens Saxenda® 6mg/ml Liraglutide solution for injectionBox of Mysimba 8mg/90mg naltrexone/bupropion hydrochloride 112 prolonged-release tablets
Overview Weight loss tabletsWeight loss injectionWeight loss tablets
  Active ingredient(s)
Active ingredient(s) OrlistatLiraglutideNaltrexone & bupropion
  Who can take it
Who can take it BMI over 30 (or 27)BMI over 30 (or 27)BMI over 30 (or 27)
Features Reduces dietary fat absorption Reduces appetite Reduces appetite & increases energy expenditure
Breastfeeding UnsuitableUnsuitableUnsuitable
Pregnant Not recommendedUnsuitableNot recommended
Application TabletInjectionTablet
  How to take
How to take 3 daily tabletsDaily injectionDaily tablet(s)
Price £79.99£74.99£134.99
View treatmentView treatmentView treatment

What others say about us

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How does it work?

Select Select your treatment and complete our online consultation.
Free consultation


Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.


If you know what you want, the quickest way to find a specific medication is to use the search bar here.


Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.


If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe Our doctors review your order.
Free prescription


As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.


If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).


Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery


All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.


We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).


All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off


With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.


There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.


There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!