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HRT | Active ingredient(s): Norethisterone acetate & Estradiol hemihydrate | Manufacturer: Novo Nordisk

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  • Review by a qualified doctor
  • Including prescription
  • Next-day delivery included

How does Kliovance work?

Women who reach menopause begin to produce less oestrogen naturally. The reduction in oestrogen levels in the blood stream can lead to a number of difficult symptoms. These symptoms can include hot flushes, irregular bleeding, vaginal itching, mood fluctuations and weight gain.

HRT is prescription medication that can help replace and maintain oestrogen levels in the blood. Supplementing oestrogen levels in this way can help to treat the symptoms associated with menopause, thus leading to a significant improvement in the quality of life.

The oestrogen in Kliovance helps alleviate these symptoms whilst the progestogen helps to balance this rise in oestrogen levels. Oestrogen can have a damaging impact on the womb lining. The progestogen helps protect the womb lining and so dramatically reduces the risk of any adverse reaction.

What are the benefits of Kliovance?

This is an effective treatment for the distressing symptoms of menopause that can occur due to decreased oestrogen production. Kliovance can help to maintain a healthy level of hormones in the blood stream and provide significant relief from menopausal symptoms.

Kliovance can also help minimise the increased risk of developing osteoporosis during menopause. The lack of oestrogen can lead to a weakening of bones, which increases the chances of them breaking. An increased level of oestrogen in the blood will reduce the risk of this occurring. Whilst this should not be a first line treatment for this condition, it can have a positive effect in dealing with it.

Who can use Kliovance?

As it contains both oestrogen and progestogen, women who have not had a hysterectomy can use Kliovance. If a hysterectomy has been completed, you may be more suitable for some of the oestrogen only HRT treatments. You can only buy Kliovance online if it has been recommended for you by your doctor. You should always consult with your doctor before deciding on a course of Kliovance. You will also need to have regular gynaecological check-ups when using this treatment to ensure that it is the right option for you.

As with all prescription medication, there are people who may not be suitable for Kliovance. This may not be the right treatment for you if you are sensitive to either oestrogen or progestogen. You may also not be suitable if you have a history of breast cancer, irregular vaginal bleeding, liver disease or circulatory issues. When you buy Kliovance online at 121doc, you will need to complete an online medical questionnaire.Our doctors will use the details that you provide to determine whether this is a suitable treatment option for you.

How to use this treatment?

Kliovance comes in a 1mg tablet that you are required to take once per day for the entirety of the 28-day cycle. The medication comes in a calendar marked pack, which is designed to help you keep track of your treatment. You should take each tablet with a glass of water as this will help reduce the possibility of indigestion and nausea. You can take each tablet with or without food.

To see the benefit of this medication, you should ensure that you take it as per the instructions. If you miss a day, you should not then take two tablets the following day. You should never exceed the 1mg dosage of Kliovance in a single day. You will be provided with a detailed patient leaflet, which will have information and instructions about this medication and how to use it. We require that you read this patient leaflet before beginning the treatment.

What are the Kliovance side effects?

The presence of progestogen in this treatment significantly reduces the risk of any side effects associated with oestrogen. This also means that women who have not had a hysterectomy can use Kliovance. As with other HRT treatments, there is the potential risk of side effects in very rare cases. These can include nausea, indigestion, headaches, fluid retention and leg cramps. Experiencing symptoms of this nature is often a sign that your body has begun adjusting to the treatment. If you experience anything more serious, you should inform your doctor. It is also important that your doctor monitors you whilst you are using HRT.

How to buy Kliovance online?

At 121doc, we understand that it can often be difficult finding the time to go see your doctor whenever you need a new pack of medication. You can buy Kliovance online by simply completing a medical questionnaire, which our doctors will use to determine whether this is the correct treatment option for you. Please find an alternative medication on our HRT treatment page if you find that Kliovance is not the correct medication for you. If the doctor approves your order, a prescription will be created and sent to our UK pharmacy to be dispensed on the same day. We offer next day delivery to all of our customers at no extra cost.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.


What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
Is the price all-inclusive?
Can I place more than one order at a time?
What are my delivery options?
Is it safe to buy prescription medication online?
How do I know which treatment is best for me?
Is this service discreet?
What is included in the online consultation?

Our consultations include general questions about your health (e.g. blood pressure levels, current and past conditions), as well as specific questions related to your selected treatment. We will also request relevant personal information to complete payment and delivery.

All questions are necessary, and your answers and details will not be shared with any third-parties. Only our doctors have access to your medical information.

Will a doctor review my consultation?

It is a legal and medical requirement that a doctor first reviews all completed consultations. We have a team of in-house doctors and specialists who will ensure your selected treatment is safe for your use. All information is stored securely and confidentially.

Please note, we do not guarantee that our doctors will approve treatment.

What happens after I submit my order?

Your consultation will be sent directly to our medical team, where it will be reviewed by one of our doctors.

If your chosen treatment is deemed suitable for your use, they will issue a prescription. Your prescription is then forwarded to our pharmacy, where your medication will be dispensed and dispatched for courier delivery.

Is the price all-inclusive?

Yes. All 121doc orders include a medical consultation, a prescription and next-day delivery. There are no additional costs. We believe in providing a safe and easy-to-use service.

Can I place more than one order at a time?

Yes. However, certain medications may negatively interact with each other. Our doctors may not approve your order on this basis.

You can place multiple items in one basket, and complete a consultation for all.

If you wish to place a second order for a different medication, you will have to complete a separate consultation.

What are my delivery options?

We offer several delivery options:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not available, a friend or relative can sign in your place.

None of these options will incur an additional charge.

Is it safe to buy prescription medication online?

To ensure you are purchasing from a reputable company, you should look to see their country’s regulatory bodies verify them.

In the UK, this is the Care Quality Commission (CQC) and the Medicines and Healthcare products Regulatory Agency (MHRA).Certificates can be viewed here.

How do I know which treatment is best for me?

Some treatments also offer the 'Advise Me' function. You will be asked questions about your lifestyle and needs, plus medical questions. You will then be presented with the advice of our doctors.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also regularly inspected by various UK regulatory agencies, such as the Information Commissioner's Office (ICO).

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

What others say about us

4.6 score - 8523 Reviews

How does it work?

Select Select your treatment and complete our online consultation.
Free consultation


Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.


If you know what you want, the quickest way to find a specific medication is to use the search bar here.


Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.


If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe Our doctors review your order.
Free prescription


As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.


If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).


Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery


All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.


We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).


All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off


With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.


There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.


There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!