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Malarone

Malaria|Active ingredient(s): Proguanil hydrochloride & Atovaquone|Manufacturer: GSK

Woman taking tablets on an airplane

Don’t let Malaria get in the way of your holiday

  • Effective protection against malaria
  • Fewer side effects than other antimalarials
  • Suitable for short or long trips
  • Convenient once-daily dosing
  • 250 mg/100 mg film-coated tablets

How to use

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Prepare for your trip

Start taking Malarone 2 days before your trip (1 tablet per day).

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Once-daily dosing

Take 1 tablet once daily for the duration of your stay.

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Continue for added protection

Continue taking Malarone for 7 days once you’ve returned.

What others say about Malarone

Trustpilot review
2 reviews with score 5

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Price is all-inclusive.
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Malarone

What is Malarone?

Malarone is an antimalarial tablet used to prevent or treat malaria when traveling to a place with a high risk of the disease. By taking Malarone once daily before, during and after your trip, you can protect yourself from malaria and enjoy your holiday worry-free. At 121doc, we prescribe 250 mg/100 mg Malarone tablets specifically for preventing malaria.

How does Malarone work?

Malarone works by interfering with enzymes in the malaria parasite (plasmodium falciparum), stopping the disease from spreading. It does this through its two active ingredients: proguanil hydrochloride and atovaquone. With the malaria infection prevented from spreading, your body’s immune system can effectively kill the virus and symptoms should subside.

How effective is Malarone?

Malarone antimalarial tablets are over 95% effective at protecting against malaria according to clinical studies.

Research also suggests that atovaquone-proguanil tablets like Malarone may be particularly effective for travellers visiting areas with a high resistance to other antimalarials. Studies also show Malarone is one of the most well-tolerated antimalarial medications, offering a lower chance of side effects without sacrificing effectiveness.

Who can use Malarone?

Malarone antimalarial tablets can be prescribed to people over 18 years old travelling to an area with a high-risk of malaria. There is only one dose of Malarone: 250 mg atovaquone/100 mg proguanil hydrochloride per tablet.

Do not take Malarone if you:

  • are allergic to atovaquone, proguanil hydrochloride, or any other ingredient in this medicine
  • have severe kidney disease
  • are pregnant or breastfeeding

How do I take Malarone for malaria prevention?

The recommended Malarone dose is 1 tablet once per day, preferably with food or milk. Here is the general timeline to follow:

  1. Start taking Malarone 2 days before you travel to a high-risk area.
  2. Take it for the entire duration of your trip.
  3. Continue taking it for 7 days after your return to a malaria-free area.

It is important to take Malarone for the full course to ensure full protection. Stopping early can risk you getting malaria.

What if I miss a dose of Malarone

If you forget to take a dose of Malarone, skip the missed dose and take your next one at the usual time. Do not take a double dose to make up for a missed one. It is very important you take the full course to ensure protection against malaria.

What are the side effects of Malarone?

While generally tolerated better than other antimalarials like Mefloquine and Doxycycline, Malarone can cause some side effects.

The most common Malarone side effects include:

  • headache
  • nausea and vomiting
  • stomach pain
  • diarrhoea

This is not an exhaustive list. For a full list of Malarone’s side effects, consult the patient information leaflet. If your Malarone dosage is causing side effects, speak to your doctor about possible changes to your treatment plan.

How long do Malarone side effects last?

Most side effects from Malarone malaria tablets should disappear 1-2 days after you stop taking it. Side effects may persist for the entirety of treatment, but they can also go away as your body gets used to the medication.

To avoid or reduce the severity of side effects, take Malarone with food or a milky drink. This is especially helpful for side effects like headache, nausea, vomiting, and stomach pain, and can also make treatment more effective.

Is Maloff the same as Malarone?

Maloff and Malarone are both antimalarial treatments containing 250 mg atovaquone and 100 mg proguanil hydrochloride. Since they contain the same active ingredients, they work in the same way to prevent malaria.

The only differences between the two antimalarial tablets are brand name, manufacturer, and the fact that Maloff is available without a prescription in some countries. Generic atovaquone/proguanil hydrochloride tablets may also come in a different dosage, although the general dose of 250 mg/100 mg is the standard.

Is there a generic version of Malarone?

Yes, there are generic versions of Malarone. Generic atovaquone/proguanil hydrochloride tablets are medically equivalent to Malarone, meaning they contain the same ingredients and work in the same way. However, there are some differences, such as packaging and manufacturer. Generic Malarone tablets are not available from 121doc.

What’s the best time of day to take Malarone?

You can take your Malarone tablets whenever suits your lifestyle best. There are no specific guidelines detailing when to take them, as long as you take them with food or a milky drink at the same time every day if possible.

What’s the difference between Malarone and Doxycycline?

Both Malarone and Doxycycline are effective medicines used for malaria prevention, but there are some things that separate them:

  • Regional differences: some strains of the malaria virus are resistant to Doxycycline, so Malarone is preferred when travelling to parts of the world where these strains are found.
  • Post-travel dosing: Malarone only requires you to use it for 7 days after returning from your travels, whereas Doxycycline needs to be taken for 4 weeks once you’re back.

Keep these factors in mind when deciding which antimalarial treatment is most suitable for your needs. See more information and compare your options for malaria prevention here.

Can I get Malarone without a prescription?

No, you cannot get Malarone malaria tablets without a prescription from a licensed healthcare provider. Safety is our number one priority at 121doc, and our doctors will only prescribe treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects
Medical review byDr. Caroline FontanaLast review 15 December 2025
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Malarone Overview

Type of medicine Antimalarial
Used for Preventing malaria
Active ingredient Atovaquone and proguanil hydrochloride
Works by Stopping the malaria infection from spreading, allowing the body’s immune system to clear the infection
Effective within Continuous protection throughout your trip when treatment is started 2 days before you go
Available as Film-coated tablets
Available dosage(s) 250 mg atovaquone/ 100 mg proguanil hydrochloride
Usage instructions Take 1 tablet every day of your trip starting 2 days before you leave, and ending 7 days after you’ve returned
Packaging Blister packs containing 12 tablets
Manufacturer GlaxoSmithKline
Generic available? No

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

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Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

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If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

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Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
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Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

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There are two ways to subscribe. The first is during the order process. The second is via your profile here.

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There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!