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HRT | Active ingredient(s): Conjugated oestrogens & Medroxyprogesterone acetate | Manufacturer: Pfizer

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  • Review by a qualified doctor
  • Including prescription
  • Next-day delivery included

How does Premique work?

As a woman reaches menopause, the body goes through some significant changes. One of these changes is a gradual decrease in the amount of oestrogen that the body can naturally produce. Whilst this is normal, it can lead to some difficult symptoms that can be hard to live with. The symptoms of menopause can include night sweats, mood variations, vaginal itching, headaches and hot flushes.

Premique has conjugated oestrogen and medroxyprogesterone as active ingredients, making it suitable for women with menopause symptoms who have not had a hysterectomy. The conjugated oestrogen is a naturally occurring form of this hormone that works to replenish the decreased oestrogen levels in the blood stream. By supplementing the hormone levels in this way, Premique is an effective treatment for women who require assistance in managing and treating the symptoms of menopause.

While supplementing oestrogen in the blood stream can help treat the adverse reactions that can occur at menopause, it can also have a damaging effect on the womb lining, allowing it to grow in an unregulated way. It is for this reason that oestrogen only HRT treatments are only recommended for women who have had a hysterectomy (surgical removal of the womb). As Premique contains progestogen, it acts to balance the rise in oestrogen. The presence of progestogen helps reduce the risk of any potential complications and decrease the risk of any potential growth of the womb lining.

What are the benefits of Premique?

Premique is an effective treatment for the symptoms of menopause. It contains both oestrogen and progestogen, so there is a reduced risk of any potential adverse reactions from the increased levels of oestrogen. The presence of progestogen also means that women who have not had a hysterectomy are able to use this medication.

Who can use Premique?

This HRT treatment is typically designed for women who have not had a hysterectomy and who are experiencing menopausal symptoms. You may not be suitable to use Premique if you have a history of cancer associated with oestrogen, breast cancer, circulatory issues, liver disease or irregular vaginal bleeding. You may also not be suitable for this medication if you have (or have had) a condition that increases your risk of blood clotting. You should also not use this treatment if you are allergic to either conjugated oestrogen or medroxyprogesterone.

At 121doc, we will only be able to provide Premique to women who have had this treatment recommended by a doctor. If you have not been recommended this treatment, you should first consult with a specialist to establish what the correct treatment option for you is. When using Premique, it is important that you have regular check-ups with your doctor about your treatment.

When you buy Premique online at 121doc, you will be required to complete a quick online medical consultation. Our doctors will use the information from this consultation when determining whether this is the correct treatment for you. It is important that you include as much medical information as possible. You should also include any medications that you are currently taking, as the way that Premique works may be affected by other medications. If you are unsure of how to place your order, or whether this is the correct treatment for you, please feel free to contact our customer care team who will be happy to assist you further.

How do you use Premique?

Premique comes into two separate dosages, so it is important that you select the correct strength when you are placing your order. Your doctor may prescribe the lower dosage at first and then increase it if you are not at risk of side effects or if a stronger dosage of hormones is required to ease your symptoms.

It is important that you take Premique as your doctor has instructed you to do so. Each pill be calendar marked, which is designed to help you keep track of your treatment. Only take one tablet per day with water, before or after food. You will be provided with a patient leaflet when you place your order that has full instructions on how and when to use your treatment. If you miss a pill, you should refer to the patient leaflet for guidance.

What are the side effects?

As with all prescription medications, there is a small risk of side effects when using Premique. These can include breast tenderness, weight fluctuations and leg cramps. Normally these will pass once the body has adjusted to the treatment. If you experience anything that causes you significant discomfort, you should discontinue the treatment and refer to a doctor.

How to buy Premique online?

You can buy Premique online at 121doc without a doctor's appointment. It is important to note that we are only able to provide a HRT treatment that has been recommended to you by your doctor. Simply select the dosage that you require and then proceed to the quick online medical questionnaire. Once completed, your order details be reviewed by our doctor. If the doctor approves the order, a prescription will be created and the medication dispatched from our registered UK pharmacy. Our quick and discreet delivery services mean you could receive your medication on the next day of placing your order. If you are unable to use Premique then you can find an alternative on our HRT treatments page.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.


What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
Is the price all-inclusive?
Can I place more than one order at a time?
What are my delivery options?
Is it safe to buy prescription medication online?
How do I know which treatment is best for me?
Is this service discreet?
What is included in the online consultation?

Our consultations include general questions about your health (e.g. blood pressure levels, current and past conditions), as well as specific questions related to your selected treatment. We will also request relevant personal information to complete payment and delivery.

All questions are necessary, and your answers and details will not be shared with any third-parties. Only our doctors have access to your medical information.

Will a doctor review my consultation?

It is a legal and medical requirement that a doctor first reviews all completed consultations. We have a team of in-house doctors and specialists who will ensure your selected treatment is safe for your use. All information is stored securely and confidentially.

Please note, we do not guarantee that our doctors will approve treatment.

What happens after I submit my order?

Your consultation will be sent directly to our medical team, where it will be reviewed by one of our doctors.

If your chosen treatment is deemed suitable for your use, they will issue a prescription. Your prescription is then forwarded to our pharmacy, where your medication will be dispensed and dispatched for courier delivery.

Is the price all-inclusive?

Yes. All 121doc orders include a medical consultation, a prescription and next-day delivery. There are no additional costs. We believe in providing a safe and easy-to-use service.

Can I place more than one order at a time?

Yes. However, certain medications may negatively interact with each other. Our doctors may not approve your order on this basis.

You can place multiple items in one basket, and complete a consultation for all.

If you wish to place a second order for a different medication, you will have to complete a separate consultation.

What are my delivery options?

We offer several delivery options:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not available, a friend or relative can sign in your place.

None of these options will incur an additional charge.

Is it safe to buy prescription medication online?

To ensure you are purchasing from a reputable company, you should look to see their country’s regulatory bodies verify them.

In the UK, this is the Care Quality Commission (CQC) and the Medicines and Healthcare products Regulatory Agency (MHRA).Certificates can be viewed here.

How do I know which treatment is best for me?

Some treatments also offer the 'Advise Me' function. You will be asked questions about your lifestyle and needs, plus medical questions. You will then be presented with the advice of our doctors.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also regularly inspected by various UK regulatory agencies, such as the Information Commissioner's Office (ICO).

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

What others say about us

4.6 score - 8523 Reviews

How does it work?

Select Select your treatment and complete our online consultation.
Free consultation


Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.


If you know what you want, the quickest way to find a specific medication is to use the search bar here.


Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.


If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe Our doctors review your order.
Free prescription


As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.


If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).


Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery


All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.


We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).


All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off


With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.


There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.


There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!