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Premarin

HRT|Active ingredient(s): Conjugated oestrogens|Manufacturer: Pfizer

What others say about Premarin

Trustpilot review
25 reviews with score 5

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Price is all-inclusive.
Consultation is included.
Prescription is included.

Free shipping.
UK: Free next-day delivery.
Discreet packaging.

Licensed doctors.
Registered pharmacies.
Certified online pharmacy.

Premarin

How Premarin works

Premarin is a type of HRT treatment that contains conjugated oestrogen, which is essentially a combination of different oestrogens that are very natural to the female body. It helps because it replaces oestrogen that is lost during menopause, restoring hormone balance to a healthy level.

Using it doesn’t just help take away symptoms such as night sweats, hot flushes, vaginal dryness and changes in sex drive, but can also prevent significant loss of bone mass that can lead to osteoporosis.

Who can take Premarin

It is available to women who have had a hysterectomy and who require relief from menopause symptoms. You may not be prescribed this treatment if you have a history of breast cancer, endometriosis and fibroids. This medication should also not be taken or taken in an adjusted dose if you are already using treatments for tuberculosis or HIV or you are taking St John’s wort or myterapone.

How to take it

Available doses of Premarin include 300mcg, 625mcg and 1.25mg dose. You’ll likely be prescribed the lowest dose to start off with, although this may be increased if you require it and you haven’t displayed any worrying side effects.

It’s a daily treatment, meaning that there is no break in between pill packs. If you have not had a hysterectomy, a doctor may prescribe an alternative treatment or additional clinical progestogen to be taken for a few days of your cycle.

The side effects of Premarin

All patients on HRT treatment should be monitored vigilantly by their doctor, but this still doesn’t mean that side effects should be a great concern, especially if you are on the right medication for you.

Common side effects may include abdominal pain, headache, nausea, nervousness, back pain, vaginal bleeding or joint pain. You may also experience spotting or changes in your sex drive. These side effects shouldn’t be lasting, but if they start to bother you, always tell a doctor.

Please note that using additional oestrogen may increase your risk of stroke, breast cancer, heart attack or blood clots, although your doctor will be keeping an eye out for any warning signs associated with these conditions.

Ordering Premarin online

121doc provides you the chance to get a repeat prescription online. Our service aims to be convenient, safe and quick, but we ask all patients to complete a consultation form so that we can ensure your safety before we send any treatments to you. All consultations are checked by our doctor, who will provide a prescription if it's safe to do so. This prescription is passed to our pharmacy where our pharmacist will double-check it and dispense your treatment for secure next day delivery. We have many HRT treatments available to buy online. If for any reason you cannot be prescribed Premarin then please find an alternative on our HRT treatments page.

Medical review byDr. Caroline FontanaLast review 26 May 2025
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

Select
Select Select your treatment and complete our online consultation.
Free consultation

Conditions:

Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.

Treatments:

If you know what you want, the quickest way to find a specific medication is to use the search bar here.

Ordering:

Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

Help:

If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe
Prescribe Our doctors review your order.
Free prescription

Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery

Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat
Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off

Repeat:

With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

Save:

There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!