Mercilon
Combined Pill|Active ingredient(s): Ethinylestradiol & Desogestrel|Manufacturer: Various
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Mercilon
What is Mercilon?
Mercilon is a combined oral contraceptive pill that is over 99% effective when used correctly. It contains synthetic versions of oestrogen (ethinylestradiol) and progestogen (desogestrel) to reliably and safely prevent pregnancy. It is sometimes referred to as “the pill”.
How does Mercilon work?
Mercilon works in three core ways to prevent pregnancy:
- Prevents ovulation: Mercilon prevents the release of hormones that trigger ovulation. With no egg released, fertilisation cannot occur.
- Thickens cervical mucus: Mercilon makes cervical mucus thicker, making it harder for sperm to pass through.
- Alters the uterine lining: Mercilon modifies the lining of the womb, making it almost impossible for a fertilised egg to attach to it and grow.
Together, these actions provide highly effective, reliable protection against pregnancy.
How effective is Mercilon?
The combined oral contraceptive pill Mercilon is over 99% effective at preventing pregnancy when used correctly. In one study involving 1,684 women, four pregnancies occurred, with three of them a result of patients not taking Mercilon correctly. This displays a very high rate of effectiveness makingMercilon one of the most reliable contraceptive options on the market when used as directed.
Who can use it?
To be prescribed Mercilon from 121doc, you must be a woman over the age of 18.
Do not use Mercilon if you:
- are allergic to any ingredient found in this medicine
- have ever had a blood clot or a disorder affecting blood clotting
- are due to have surgery or will be immobile for a long time
- have ever had a heart attack or stroke
- have angina pectoris (a condition causing severe chest pain) or transient ischaemic attack (temporary stroke symptoms)
- experience migraines with aura
- have ever had liver disease, a liver tumour, or kidney problems
- have ever had breast cancer or cancer of the genital organs
- experience unexplained vaginal bleeding
When should I start taking Mercilon?
When you take your first Mercilon pill depends on a few different factors. Follow this guide when starting your birth control:
-
If you have not used hormonal contraception in the last month:
- Start on day 1 of your period for immediate protection.
- Starting on days 2–5 requires extra protection (i.e. condoms) for 7 days.
-
If you’re switching from another combined pill, ring, or patch:
- Start the day after your last active tablet or after removing your ring/patch.
- Begin at the latest after your placebo or tablet-free days.
-
If you’re switching from a progestogen-only pill:
- You can start on any day, but use extra protection for 7 days.
-
If you’re switching from an injection, implant, or hormonal IUD:
- Start on the day your next injection is due, or the day your implant is removed. Use extra protection for 7 days.
-
After a miscarriage:
- Follow your doctor’s advice.
-
After giving birth:
- Start between 21 and 28 days after giving birth. Starting later requires extra protection for 7 days.
Can I take Mercilon without a break?
Yes, you can take Mercilon without the 7-day break to avoid breakthrough bleeding, however, you should discuss this with your doctor to make sure it’s safe. Generally, it is advised to take a 7-day break every month to keep your cycle under control, but in some cases this is not necessary.
What if I miss a pill?
If you forget to take a Mercilon pill, you may be less protected from pregnancy, but it depends on how long it has been since you were meant to take it. Follow this guide on what to do if you forget to take a pill:
| How long it has been | What to do | Extra contraception needed? |
|---|---|---|
| Less than 12 hours | Take the forgotten pill as soon as possible, and take your next one at the usual time. This may mean taking two pills in the same day | No |
| More than 12 hours | Take the most recently missed pill straight away, and your next one at the usual time. This may mean taking two pills in the same day | Use condoms for the next 7 days. If there are fewer than 7 pills left in the pack, start your next strip without a break once you have finished your current one |
Are there any side effects of Mercilon?
Yes, there are some potential side effects of Mercilon, although not everyone will get them. The most common Mercilon side effects are:
- headache
- weight gain
- breast tenderness
- depression or mood changes
- stomach problems
- migraine
- fluid retention
- vomiting
- diarrhoea
This is not an exhaustive list. For a full list of Mercilon’s side effects, consult the patient information leaflet.
Does Mercilon cause weight gain?
Mercilon can cause weight gain, as it is listed as a common side effect. However, this is most likely a result of fluid retention (water weight), not fat gain. This happens as your body gets used to hormonal changes, and your weight should go back to normal within weeks. If it doesn’t, talk to your doctor to determine what the cause could be.
Does Mercilon cause acne?
While Mercilon can sometimes cause skin problems like acne, it is actually more likely to improve symptoms. A comprehensive review of over 31 clinical trials found that combined contraceptive pills like Mercilon reduced spots and improved skin.
Does Mercilon make your breasts bigger?
Mercilon can cause your breasts to enlarge slightly due to its hormones. This is likely due to fluid retention, and is often temporary. Once your body gets used to the medication, your breasts should go back to their normal size, but they may stay enlarged until you stop taking Mercilon.
Can I take Mercilon while breastfeeding?
No, Mercilon is not recommended while breastfeeding as it can interfere with your baby’s development. Research has found that this is likely due to a decrease in breast milk production due to the hormonal content of Mercilon. Talk to your doctor about alternative contraception options if you’re breastfeeding.
Can I get Mercilon without a prescription?
No, you cannot get Mercilon without a prescription. Safety is our number one priority at 121doc. For this reason, our doctors will only prescribe treatment if you meet the criteria in your online consultation.
A prescription from a trusted healthcare provider like 121doc ensures:
- safety during treatment
- effective results
- monitoring of side effects

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.
Mercilon Overview
| Type of medicine | Combined oral contraceptive |
| Used for | Contraception |
| Active ingredient | Ethinylestradiol and Desogestrel |
| Works by | Preventing ovulation, thickening cervical mucus to block sperm, and making the womb lining less suitable for implantation |
| Effective within | Immediately when started on the first day of your menstrual cycle. After 7 days if started on days 2-5 |
| Available as | Film-coated tablets |
| Available dosage(s) | Ethinylestradiol 20 mcg / Desogestrel 150 mcg |
| Usage instructions | Take one tablet per day for 21 days, followed by a 7-day break |
| Packaging | Blister pack containing 21 tablets |
| Manufacturer | Organon |
FAQs
What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.
Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.
How does it work?
What you need treatment for:
On each page, we provide information as well as treatment options we currently offer. To begin your consultation, select what you need treatment for from the top menu and simply choose "Start consultation" on the selected page.
Treatments:
You can read more about our treatment options on our treatment information pages. To search for a specific medication, simply use the search function.
You will be presented with your recommended treatment option(s) after completing your online consultation.
Ordering:
Every order starts with an online consultation. We will ask you medical questions to make sure that only treatments that are safe and effective are prescribed. We take into account your lifestyle, health and any other medications you’re currently using.
The consultation is completely free and takes between 5 and 10 minutes of your time.
All your information is safe with us. We don’t share it with anyone unless you want us to.
Help:
If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.
Review:
As soon as you place your order, one of our doctors will review your consultation.
Questions:
If the doctor has any additional questions, you will receive a phone call or an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can contact you at a more convenient time if necessary.
Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).
Pharmacy:
Once our pharmacy receives your prescription and dispatches your treatment, you will receive a second email with the tracking number.
Always free. Discreet packaging.
Free:
Express delivery is included with all orders. Alternatively, you can select a delivery date that suits you better.
Convenient:
You can check the estimated delivery time using your tracking number. All we need is your signature (or a friend's or family member's).
Discreet:
All parcels are plainly labelled; there is no logo or any indication of their contents.
Repeat:
With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.
The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.
Subscribe:
There are two ways to subscribe. The first is during the order process. The second is via your profile here.
You can cancel or amend your repeat prescriptions at any time.
Save:
There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!