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Tadalafil

Erectile Dysfunction|Active ingredient(s): Tadalafil|Manufacturer: Various

A sporty man with headphones around his neck taking a tablet

The Weekend Pill: Long-Lasting Erections within 30 Minutes

  • Stronger erections for up to 36 hours
  • Works in 30-60 minutes
  • As-needed dosing
  • Trusted by millions worldwide
  • Available in 2.5 mg, 5 mg, 10 mg, and 20 mg doses

How to take

A man with a Tadalafil tablet in his hand.

Choose your moment

Take your tablet 30-60 minutes before you plan to have sex.

A smiling couple looking at each other.

Set the stage

For best results, take Tadalafil on an empty stomach in an environment you feel comfortable in.

Hand touching the face of an analog clock.

Make it count

Tadalafil should last for up to 36 hours, so make the most of your time.

What others say about Tadalafil

Trustpilot review
257 reviews with score 4.8

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Consultation is included.
Prescription is included.

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UK: Free next-day delivery.
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Tadalafil

What is Tadalafil?

Tadalafil is an erectile dysfunction treatment. Commonly sold under the brand name Cialis, it helps men achieve stronger and longer-lasting erections for up to 36 hours after dosing.

Originally intended to treat heart disease, Tadalafil (generic Cialis) was found in clinical trials to be an effective treatment for erectile dysfunction. Since then, it has become one of the most trusted and widely used ED treatments in Europe, helping men regain their confidence in the bedroom and enjoy a more satisfying sex life.

Is Tadalafil the same as Cialis?

Yes, Tadalafil is the generic version of the branded medication Cialis. They both contain the same active ingredient and work in the same way.

With this in mind, there are some differences. Most notably, Cialis is more expensive than its generic version, Tadalafil. While this may encourage you to choose the generic version, many people prefer Cialis as it is well-known. The manufacturer and packaging may also differ, since generics are widely produced by different manufacturers. Make sure you bear all this in mind when choosing your erectile dysfunction treatment.

How does Tadalafil work?

Tadalafil works by widening blood vessels and relaxing muscle tissues to increase blood flow to the genitals during sexual arousal. This enhanced circulation helps men achieve and maintain stronger, longer-lasting erections.

Contrary to popular belief, Tadalafil doesn’t automatically trigger an erection. It only works in response to sexual stimulation. This means you should only feel the effects when you need to.

How effective is Tadalafil?

Clinical studies have found that up to 81% of men can experience improved erections with Tadalafil.

Here are the results of one study in particular:

  • 81% of patients taking Tadalafil reported improved erections.
  • 75% of sexual encounters were successful with Tadalafil.
  • 59% of men taking Tadalafil saw their erectile dysfunction fully resolved.

Tadalafil vs Sildenafil: which is better?

Despite Sildenafil (Viagra) being the more well-known of the two erectile dysfunction medications, this study shows that patients and their partners tend to prefer Tadalafil.

Explore our Sildenafil tablets for comparison.

This is likely due to its longer duration of action—lasting for up to 36 hours compared to just 4 for Sildenafil. This offers greater flexibility and convenient dosing, earning Tadalafil the nickname “The Weekend Pill”.

How long does Tadalafil take to work?

Tadalafil should begin to take effect within 30-60 minutes of taking your dose. With this in mind, it’s best to take your tablet around an hour before you plan to have sex.

Peak effectiveness is usually felt 2 hours after you take your tablet.

How long does Tadalafil last?

Tadalafil lasts a while longer than other erectile dysfunction treatments like Sildenafil. While peak effects are felt around 2 hours after dosing, it should work for up to 36 hours.

Who can take Tadalafil?

To be prescribed Tadalafil, you must be over 18 years old and suffer from erectile dysfunction.

Do not take Tadalafil if you:

  • Have an allergy to tadalafil or any other ingredient in this medicine.
  • Are taking any medicines known as “nitrates”.
  • Have serious heart disease or have experienced a heart attack in the last 90 days.
  • Had a stroke within the last 6 months.
  • Have low blood pressure or uncontrolled high blood pressure.
  • Are taking a medicine called Riociguat (used for high blood pressure in the lungs).
  • Ever had loss of vision due to a stroke of the eye.

What dose should I take?

There are 4 doses of Tadalafil available. Consult this table to see which one is right for you:

Tadalafil dosage options:

Type Dose When to take Consideration
Daily use 2.5 mg Once daily, at the same time Gentle daily option (low dose)
Daily use 5 mg Once daily, at the same time Most common daily starting dose
As needed 10 mg 30-60 minutes before sexual activity Standard on-demand treatment
As needed 20 mg 30-60 minutes before sexual activity Stronger dose if 10 mg is not enough

IMPORTANT:

The maximum dose of Tadalafil in 24 hours is one tablet, no matter the dosage. If you take more than this, contact your doctor.

Can you take Tadalafil daily?

Since the effects of Tadalafil last for up to 36 hours, it is not recommended to take 10 mg or 20 mg tablets daily. For these doses, wait at least 36 hours between doses. This ensures safety while still allowing you to experience the full benefits of treatment.

If you would prefer daily dosing, Cialis Daily may be better suited for you. Available in 2.5 mg or 5 mg tablets, this lower-strength option supplies a steady stream of tadalafil in your blood, allowing for spontaneous sexual activity.

Please note:

It can take up to 3-5 days for 2.5 mg or 5 mg Tadalafil tablets to work. For on-demand treatment, consider 10 mg or 20 mg Tadalafil tablets instead.

Are there any side effects of Tadalafil?

Tadalafil can produce side effects, although not everyone will get them. The most common side effects of Tadalafil include:

  • headache
  • back pain
  • muscle aches
  • pain in arms and legs
  • facial flushing
  • nasal congestion
  • indigestion

For a full list of Tadalafil side effects, consult the patient information leaflet.

Does Tadalafil lower blood pressure?

Yes, studies show that Tadalafil can lower blood pressure because it relaxes and widens blood vessels.

For this reason, you cannot take Tadalafil if you are currently taking nitrates or other medications that can lower blood pressure. Tell your doctor about any other medicines you take in your consultation to ensure safety.

Can I drink alcohol with Tadalafil?

You should avoid drinking alcohol with Tadalafil (Cialis), since both can lower blood pressure, and increase the risk of side effects like headache. It can also reduce the effectiveness of Tadalafil, since alcohol can interfere with sexual function.

While avoiding alcohol altogether when taking Tadalafil is best, you may not experience problems with one or two drinks. Speak with your doctor before drinking alcohol, and note how you feel if you do.

Can I buy Tadalafil without a prescription?

No, Tadalafil can only be purchased with a prescription from a licensed healthcare professional. Safety is our number one priority at 121doc. For this reason, our doctors will only prescribe you treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects
Medical review byDr. Caroline FontanaLast review 11 September 2025
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

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How does it work?

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Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.

Treatments:

If you know what you want, the quickest way to find a specific medication is to use the search bar here.

Ordering:

Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

Help:

If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe
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Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery

Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat
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Repeat:

With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

Save:

There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!