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Zoely

Combined Pill|Active ingredient(s): Nomegestrol acetate & Estradiol|Manufacturer: Various

A young woman taking a white tablet with a glass of water

Zoely: Combined Action for Reliable Protection

  • Over 99% effective at preventing pregnancy
  • Can make periods lighter and less painful
  • Simple daily dosing
  • Combined pill mimicking natural hormones
  • 2.5 mg/1.5 mg film-coated tablets

How to use

A woman taking a tablet with a glass of water

Get started

Begin with the first Zoely pill in your pack on day 1 of your period.

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Stay on track

Take one white pill daily for 24 days, followed by one yellow pill daily for 4 days.

A woman in a pink t-shirt with her hands on her hips, shown from neck to torso

Reset your cycle

Start your next pack after all pills in the current one have been taken. You may experience a withdrawal bleed while taking the yellow pills.

What others say about Zoely

Trustpilot review
21 reviews with score 5

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Zoely

How does Zoely work?

Zoely is a combined pill containing synthetic versions of oestrogen and progestogen to trick your body into thinking ovulation has occurred. This stops the ovaries from releasing an egg, making pregnancy highly improbable.

In addition to this, Zoely thickens cervical mucus and thins the lining of the uterus so that even if an egg is released, it’s harder for sperm to reach it and less likely for it to implant. Together, these mechanisms make pregnancy close to impossible.

How is Zoely different from other contraceptive pills?

Zoely differs from other combined pills in that it contains a form of oestrogen that is structurally identical to the oestrogen found naturally in the body. By containing this form of oestrogen, Zoely offers natural protection from pregnancy that doesn’t sacrifice effectiveness.

How effective is Zoely?

The Zoely pill is over 99% effective at preventing pregnancy when taken correctly, but when accounting for misuse, this drops to around 93%, as shown here.

Clinical research supports this, with one study finding that combined pills like Zoely containing nomegestrol acetate and estradiol are likely to cause only 1 pregnancy per 100 women taking it for a year, translating to a success rate of around 99%.

Who can use Zoely?

Only women aged 18 or over can be prescribed Zoely from 121doc.

Do not take Zoely if you have:

  • an allergy to any ingredient found in this medicine
  • ever had a blood clot or a condition affecting clotting
  • a surgery coming up
  • ever had a heart attack or stroke
  • ever had angina pectoris (a condition causing severe chest pain) or transient ischaemic attack (temporary stroke symptoms)
  • experienced migraine with aura
  • experienced inflammation in the pancreas
  • ever had liver disease, a liver tumour, or kidney problems
  • meningioma (a tumour between the brain and skull)
  • ever had breast cancer or cancer of the genital organs
  • experienced unexplained vaginal bleeding

Zoely is also not recommended for women over 35 who smoke. Ask your doctor about alternative treatments if you are unable to take combined pills like Zoely.

When should I start taking Zoely?

When to take your first Zoely pill depends on a few different factors. Consult this guide if you’re unsure:

Situation Advice Additional contraception needed?
No hormonal contraceptive used in the past month Take your first tablet on the first day of your period. No
Changing from another combined hormonal contraceptive (pill, ring, or patch) Take your first tablet the day after the last active pill in your current pack. If there are inactive tablets or a pill-free break, skip this. No
Changing from a combined hormonal ring or patch Start taking Zoely on the day you remove your ring or patch No
Changing from a progestogen-only pill (“minipill”) Stop taking your current pill and start with Zoely the next day. Yes, a barrier method (like condoms) for 7 days
Changing from a progestogen-only injectable, implant, or intraurine system Start taking Zoely on the day your next injection is due or the day your implant or IUS is removed. Yes, a barrier method (like condoms) for 7 days
After having a baby Take your first Zoely pill between 21 and 27 days after giving birth Not if started between days 21 and 27 after giving birth. If started after day 27, use condoms for 7 days
After a miscarriage or abortion Follow your doctor’s advice Follow your doctor’s advice

How long does Zoely take to work?

In most instances, starting Zoely on the first day of our period ensures immediate protection. That means no additional contraception is needed once you’ve started.

However, if you start on any other day, or you’re switching from a progestogen-only pill, injectable, implant, or intraurine system, it can take up to a week before Zoely protects you from pregnancy completely. In this case, use condoms for 7 days after your first pill.

How do I take Zoely?

Zoely contains 28 tablets in each pack: 24 active (white) tablets, and 4 inactive (yellow) ones. To prepare your pack, choose the sticker beginning with the current day of the week and attach it to the blister. This helps you keep track of which tablet you need to take and makes it easier to remember if you have taken it already.

Then, take 1 tablet daily until you reach the end of your pack. Once you’ve taken the last one, start the next one the very next day without taking a break. You should experience a small withdrawal bleed during the last 4 days of your pack.

What if I miss a pill of Zoely?

If you forget to take Zoely, you risk being less protected against pregnancy. What you do next depends on how long it’s been and which tablet you’ve forgotten to take.

If you are:

  • Less than 12 hours late: Take the forgotten pill as soon as possible, and take your next one at the usual time. No additional contraception is required.
  • More than 12 hours late: Follow the instructions below depending on which tablet you’ve missed.
    • Day 1-7: Take the missed pill as soon as possible, and take your next one at the usual time. Use barrier contraception (condoms) for the next 7 days.
    • Day 8-17: If you have missed one pill, take the missed pill as soon as possible, and take your next one at the usual time. No additional contraception is required. If you have missed more than one pill, follow the same advice but use condoms for 7 days.
    • Day 18-24: Take the missed pill as soon as possible, and take your next one at the usual time. Skip the inactive (yellow) tablets and start a new pack immediately after your last active pill. Use condoms for 7 days.
    • Day 25-28: Discard the missed inactive (yellow) pill(s) and continue taking your tablets as normal. No additional contraception is needed.

What are the side effects of Zoely?

Zoely birth control pills can cause side effects, although they are usually mild and should subside once your body gets used to the medication. In rare cases, side effects can be dangerous, for instance, if you get a blood clot. Consult your doctor if you are worried about side effects.

The most common Zoely side effects are:

  • acne
  • changes to your menstrual period
  • lowered libido (sex drive)
  • headache or migraine
  • nausea
  • breast or pelvic pain
  • weight gain

For a full list of side effects, consult the patient information leaflet sent with your order.

Can Zoely cause weight gain?

Zoely can cause weight gain in some women who take it, but this is usually a result of water retention, and tends to be temporary. This is likely due to hormonal changes, and there is no evidence that Zoely directly causes fat gain.

Can Zoely stop your period?

Yes, Zoely contraceptive pills can cause changes to your menstrual periods, including making them lighter, more or less painful, or even stopping them completely. Usually, you will experience a light withdrawal bleed during the last 4 days of each pack.

Can I get Zoely over the counter?

No, you cannot get Zoely without a prescription from a licensed healthcare provider. Safety is our number one priority at 121doc, and our doctors will only prescribe treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects
Medical review byDr. Caroline FontanaLast review 01 December 2025
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Zoely Overview

Type of medicine Combined oral contraceptive
Used for Contraception
Active ingredient Nomegestrol acetate & estradiol
Works by Preventing ovulation, thickening cervical mucus, and thinning the lining of the womb
Effective within Immediately if taken on the first day of your menstrual cycle
Available as Film-coated tablets
Available dosage(s) 2.5 mg Nomegestrol acetate/1.5 mg Estradiol
Usage instructions Take one white tablet per day for 24 days, followed by one yellow tablet per day for 4 days
Packaging Blister packs containing 24 active tablets and 4 inactive ones
Manufacturer Bayer
Generic available? No

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

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Ordering:

Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

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If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

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Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
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Free next-day delivery

Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

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There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!