This website has moved to a new location. Please visit our sister website for next day delivery.


HRT | Active ingredient(s): Estradiol hemihydrate | Manufacturer: Various


Out of stock

This product is currently not in stock. Please enter your email address so that we can inform you as soon as this medication is available again.

  • Review by a qualified doctor
  • Including prescription
  • Next-day delivery included

How Elleste works

Elleste Solo, Duet and Conti all work by dealing with the causes of symptoms that are associated with menopause, which include hot flushes, night sweats, vaginal itching and vaginal dryness. Patients experience these symptoms because oestrogen levels fall, but taking treatments can stabilise these levels, restoring hormonal balance.

Oestrogen, although helpful, can cause the womb lining to grow uninhibited, increasing the risk of cancer, which is why it's important to use progestogen to monitor this growth if you've not had a hysterectomy. In this case Elleste Duet and Duet Conti are better options.

Who can take it?

Most women can use these treatments safely if a doctor has recommended it to them. Elleste Duet and Conti are better options if you have not had a hysterectomy. Elleste Solo is safe to use without progestogen if you have already had a hysterectomy.

Reasons why your doctor may not have recommended you this medication are: if you've had a history of oestrogen-dependent cancers, you have liver disease; issues with blood clotting or you have or have had breast cancer.

The doses available

Elleste Solo, with just estradiol is available in a 1mg and 2mg dose and, just like with most HRT treatments you'll be started off on the smallest dose. Elleste Solo is also available in a patch form.

Elleste Duet comes in a 1mg dose and 2mg dose. The 1mg pack has 16 white estradiol capsules and 12 green ones. The white ones have just oestrogen and the green ones have a combination of both progestogen and oestrogen. The 2mg pack has 16 orange tablets and 12 grey tablets. The orange tablets contain 2mg estradiol and the grey ones have 2mg estradiol and 1mg norethisterone acetate.

Elleste Duet Conti requires you to take the same tablet for a total of 28 days. Each tablet has 1mg norethisterone ane 2mg estradiol.

How is Elleste taken?

Solo requires you to take the same tablet once a day for 28 days, without a break. Your doctor may prescribe clinical progestogen, to be taken alongside this treatment for 14 days, if you still have a womb.

Duet should also be taken for a total of 28 days without a break between pill packs, but contains 16 oestrogen tablets and 12 progestogen tablets that should be taken in sequence.

Taking Duet Conti is just as straightforward as taking Solo, so the same grey tablet should be taken daily for 28 days, without a break.

Are there any side effects?

Side effects are always a risk when taking HRT. Some women may experience changes in mood, nausea, indigestion, fluid retention, leg cramps or acne, which are milder side effects that tend to go away as you become accustomed to the HRT medication. However these side effects shouldn't be a worry if you are using the right treatment and you are visiting a doctor on a regular basis.

Is Elleste available online?

You can order all three Elleste treatments at 121doc with the help of our online consultation service. However, we ask that you only order these treatments from us if they've already been recommended to you by your doctor and you are going for regular check-ups. All consultations are free of charge and will be reviewed in confidence by our doctor. If they feel that you can use the treatment you have chosen safely, a prescription will be issued and then sent to our pharmacy from where your medicine will be shipped for overnight delivery at no extra charge.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.


What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
Is the price all-inclusive?
Can I place more than one order at a time?
What are my delivery options?
Is it safe to buy prescription medication online?
How do I know which treatment is best for me?
Is this service discreet?
What is included in the online consultation?

Our consultations include general questions about your health (e.g. blood pressure levels, current and past conditions), as well as specific questions related to your selected treatment. We will also request relevant personal information to complete payment and delivery.

All questions are necessary, and your answers and details will not be shared with any third-parties. Only our doctors have access to your medical information.

Will a doctor review my consultation?

It is a legal and medical requirement that a doctor first reviews all completed consultations. We have a team of in-house doctors and specialists who will ensure your selected treatment is safe for your use. All information is stored securely and confidentially.

Please note, we do not guarantee that our doctors will approve treatment.

What happens after I submit my order?

Your consultation will be sent directly to our medical team, where it will be reviewed by one of our doctors.

If your chosen treatment is deemed suitable for your use, they will issue a prescription. Your prescription is then forwarded to our pharmacy, where your medication will be dispensed and dispatched for courier delivery.

Is the price all-inclusive?

Yes. All 121doc orders include a medical consultation, a prescription and next-day delivery. There are no additional costs. We believe in providing a safe and easy-to-use service.

Can I place more than one order at a time?

Yes. However, certain medications may negatively interact with each other. Our doctors may not approve your order on this basis.

You can place multiple items in one basket, and complete a consultation for all.

If you wish to place a second order for a different medication, you will have to complete a separate consultation.

What are my delivery options?

We offer several delivery options:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not available, a friend or relative can sign in your place.

None of these options will incur an additional charge.

Is it safe to buy prescription medication online?

To ensure you are purchasing from a reputable company, you should look to see their country’s regulatory bodies verify them.

In the UK, this is the Care Quality Commission (CQC) and the Medicines and Healthcare products Regulatory Agency (MHRA).Certificates can be viewed here.

How do I know which treatment is best for me?

Some treatments also offer the 'Advise Me' function. You will be asked questions about your lifestyle and needs, plus medical questions. You will then be presented with the advice of our doctors.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also regularly inspected by various UK regulatory agencies, such as the Information Commissioner's Office (ICO).

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

What others say about us

4.6 score - 8463 Reviews

How does it work?

Select Select your treatment and complete our online consultation.
Free consultation


Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.


If you know what you want, the quickest way to find a specific medication is to use the search bar here.


Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.


If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe Our doctors review your order.
Free prescription


As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.


If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).


Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery


All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.


We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).


All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off


With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.


There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.


There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!