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Fluconazole

Thrush|Active ingredient(s): Fluconazole|Manufacturer: Various

A woman taking a white capsule with a glass of water

Effective thrush treatment with a single dose of Fluconazole

  • Fast relief from vaginal thrush
  • Directly targets candida: the fungus responsible for thrush
  • Single dose usually enough to clear your infection
  • Eases itching, burning, and discomfort within days
  • 150 mg capsule

How to use

Close up of a woman taking a capsule with a glass of water

Take your capsule

Swallow one 150 mg Fluconazole capsule with water. Usually, a single dose is all you need to tackle your yeast infection.

A hand holding a red pen to a calendar

Monitor your progress

Fluconazole works fast to ease itching, burning, and discomfort, with full relief usually seen within just a few days.

A woman in pink gym clothes stretching

Get back to normal

Enjoy fast, reliable relief within a week or so and get back to feeling comfortable.

What others say about Fluconazole

Trustpilot review
13 reviews with score 5

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Price is all-inclusive.
Consultation is included.
Prescription is included.

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UK: Free next-day delivery.
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Fluconazole

What is Fluconazole?

Fluconazole is an antifungal medication that treats a number of fungal infections. It is most commonly prescribed for yeast infections like oral thrush and vaginal thrush, where it reliably clears symptoms within a week or so. Available from 121doc both as a generic medicine and as the branded version Diflucan, either option is commonly prescribed as a first-line treatment for thrush.

How does Fluconazole work?

Fluconazole 150 mg works by directly targeting and killing candida: the fungus that is causing your yeast infection. It does this by making holes in the fungus cells, weakening them and making them unable to survive. This effectively clears even the most stubborn cases of thrush.

How effective is Fluconazole?

Fluconazole 150 mg is highly effective treating genital thrush, with only a single capsule needed to clear most infections.

Clinical research supports this. A study of 150 women with vaginal thrush found that a single dose of Fluconazole completely cleared infections in 88% of cases, and provided at least partial relief in 92%. When treating thrush affecting the genitals, Fluconazole is one of the most effective options available.

How long does Fluconazole take to work?

Fluconazole should improve symptoms of genital or oral thrush within 1-3 days, and completely clear your vaginal yeast infection within a week. Please note that while this is the average response to treatment, recovery time can vary from person to person.

Who can use Fluconazole for thrush?

To get Fluconazole capsules from 121doc, you must be over 18 years old, and receive a prescription from one of our doctors during your consultation.

Do not take Fluconazole if you are allergic to any of the ingredients found in this medicine. Also, tell your doctor if you have:

  • liver or kidney problems
  • heart disease
  • abnormal levels of potassium, calcium, or magnesium in your blood

Can a man take Fluconazole?

Yes, men can take Fluconazole for oral thrush or a genital yeast infection. Although primarily prescribed for women to treat vaginal thrush, Fluconazole remains a safe and effective option for men too. Talk with your doctor about treatment options in your consultation.

How often can you take Fluconazole for yeast infections?

You can take Fluconazole for thrush a few times a year if needed, but four or more infections could signal an underlying condition. Recurrent or stubborn thrush should always be evaluated by a doctor so they can determine the cause and put you on a treatment plan that prevents it from coming back.

How long does Fluconazole stay in the system?

The half life of Fluconazole is around 30 hours, but it can take up to 6-7 days for it to leave your system completely. Fluconazole is mostly eliminated by your kidneys, meaning most of it should pass through urine.

Can you take Fluconazole and a Clotrimazole Pessary together?

Yes, you can take Fluconazole alongside a Clotrimazole pessary, and this is an often prescribed combination treatment for thrush. However, only do so under a doctor’s supervision to ensure safety during treatment.

What are the side effects of Fluconazole?

Fluconazole or branded Diflucan can produce side effects, although not everyone will get them.

The most common Fluconazole side effects include:

  • headache
  • stomach ache
  • diarrhoea
  • nausea or vomiting
  • rash

This is not an exhaustive list. For all side effects of Fluconazole, consult the patient information leaflet.

Can I buy Fluconazole over the counter?

No, you cannot get Fluconazole capsules without a prescription from a licensed healthcare provider. Safety is our number one priority at 121doc. For this reason, our doctors will only prescribe treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects
Medical review byDr. Caroline FontanaLast review 26 November 2025
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Fluconazole Overview

Type of medicine Antifungal
Used for Thrush
Active ingredient Fluconazole
Works by Killing the candida fungus causing the infection
Effective within 1-3 days
Available as Capsules
Available dosage(s) 150 mg
Usage instructions Take one 150 mg capsule with a glass of water.
Packaging Blister pack containing 1 capsule
Manufacturer Various
Branded available? Yes, Diflucan capsules

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
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  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

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Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

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If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

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Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

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Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

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We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

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All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

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