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Vydura

Migraine|Active ingredient(s): Rimegepant|Manufacturer: Pfizer

A woman about to place a round white tablet in her mouth

Prevent and relieve migraines fast

  • Relief from migraines within 2 hours
  • Prevents future migraines with consistent use
  • Simple-to-take wafer placed under the tongue
  • Suitable to take if you have heart issues
  • Available in 75 mg oral lyophilisate tablets

How to use

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Time it right

Take Vydura as soon as you feel a migraine coming on.

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Place under tongue

Place a tablet under your tongue and let it dissolve naturally.

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Preventive use

If prescribed for prevention, use Vydura every other day.

What others say about Vydura

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Vydura

What is Vydura?

Vydura is a migraine treatment that can both prevent and relieve migraines. It comes in the form of thin tablets, known as oral lyophilisates, that are placed and dissolved under the tongue.

When used to treat migraines, they can provide full relief within two hours. When used to prevent them, they can increase the number of migraine-free days by up to 4 days per month.

They are available from 121doc as 75 mg dissolving tablets.

How does Vydura work?

Vydura works by blocking a chemical in the brain called CGRP. This chemical is what causes migraine pain and inflammation in the brain. It does this through the active ingredient rimegepant.

When rimegepant is released into the blood, it attaches to the receptor for CGRP and prevents the chemical from binding to it. This can prevent migraine pain and other symptoms like nausea, vomiting, and sensitivity to light.

How effective is Vydura?

Clinical studies on Vydura have found it to be effective in both relieving and preventing migraines. Here’s what they found:

Relieving migraines

20% of patients taking Vydura were pain-free after 2 hours, compared to just 12% taking a placebo. Additionally, 36% of patients were relieved of other migraine symptoms, including nausea and sensitivity to light and sound.

Preventing migraines

Patients taking Vydura to prevent migraines experienced roughly 4 more migraine-free days per month on average.

Who can use Vydura?

To be prescribed Vydura 75 mg, you must be over 18 years old and suffering from migraines. To be prescribed it to prevent migraines, you must also get 4 or more attacks per month.

Do not take Vydura if you are:

  • allergic to rimegepant or any other ingredient in this medicine
  • pregnant or breastfeeding

You should also ask a doctor before taking Vydura if you have kidney or liver problems, as treatment with this medicine may not be safe.

What are the side effects of Vydura?

Vydara can cause some side effects in some people, although most are mild.

The most common side effect is nausea, which occurs in up to 1 in 10 people. It’s important to report any side effects you get to your doctor so they can offer guidance.

For a full list of Vydura’s side effects, see the patient information leaflet.

How long does Vydura take to work?

When taking Vydura 75 mg to relieve migraines, it usually works within 2 hours.

Here’s what to expect when you take your wafer:

  • After 1-2 minutes: The tablet should dissolve completely under your tongue.
  • After 1 hour: You may notice some improvement in migraine symptoms, like nausea, light sensitivity, and headache. Some people report complete relief from pain by this point.
  • After 2 hours: Some people feel complete relief after this time, while for others it may take longer.

When should I take Vydura?

To treat a migraine headache, take Vydura as soon as you feel the first symptoms. Taking it sooner makes it more effective, and can shorten the amount of time you feel symptoms.

To prevent migraines, take one dose every other day. Taking it consistently supplies your body with a steady supply of rimegepant, providing around-the-clock protection.

How long can I take it for?

Provided you have a prescription from a licensed doctor, Vydura is safe to take long-term for migraine prevention. Your doctor can recommend a personalised treatment plan in your consultation.

What if I miss a dose?

If you take Vydura to prevent migraines and you forget to take a dose, skip the missed one and take your next one at the usual time. Never take more than one tablet (75 mg) per day.

Can I get Vydura without a prescription?

No, you cannot buy Vydura for migraines without a prescription from a licensed healthcare provider. Safety is our number one priority at 121doc, and our doctors will only prescribe treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects

To see if you’re eligible for treatment, all you have to do is complete a short online consultation. If approved by our medical team, your treatment will be delivered direct to your door in discreet packaging.

Medical review byDr. Caroline FontanaLast review 24 June 2026
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Vydura Overview

Type of medicine CGRP receptor antagonist (GEPANT)
Used for Migraine
Active ingredient Rimegepant
Works by Blocking a chemical in the brain that causes migraine pain and inflammation
Effective within 2 hours
Available as Oral lyophilisate (dissolving tablets)
Available dosage(s) 75 mg
Usage instructions Relief: place one tablet under your tongue at the first sign of a migraine.
Prevention: place one tablet under your tongue every other day.
Packaging Pack containing 2 oral lyophilisates (dissolving tablets)
Manufacturer Pfizer
Generic available? No
Storage Store below 30° C in the original packaging

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

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Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

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If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

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Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
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Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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Repeat:

With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

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