Get the 121doc appReorder in just 3 clicks. It’s free
View
Home / Migraine / Sumatriptan

Sumatriptan

Migraine|Active ingredient(s): Sumatriptan|Manufacturer: Various

A woman taking a tablet with a glass of water

Fast migraine relief, when you need it most.

  • Relieves migraine symptoms in as little as 15 minutes
  • Tackles migraine pain at the source
  • Taken as-needed for reliable migraine treatment
  • Available as tablets or nasal sprays
  • Available as a 20 mg nasal spray, or 50 mg & 100 mg tablets

How to use

A person holding a glass of water in one hand and a white tablet in the other

Take it early

Take a dose of Sumatriptan as soon as you feel symptoms. The earlier you take it, the better it works.

A woman lying awake in bed in a dark room

Take it easy

Rest in a dark room and avoid anything that triggers your migraines or makes them worse.

Hand touching the face of an analogue clock

Follow your treatment plan

If your migraine returns after 2 hours, you can take another dose, up to a maximum of 3 doses per day.

What others say about Sumatriptan

Trustpilot review
11,238 reviews with score 4.5

Quality healthcare
made easy

Price is all-inclusive.
Consultation is included.
Prescription is included.

Free shipping.
UK: Free next-day delivery.
Discreet packaging.

Licensed doctors.
Registered pharmacies.
Certified online pharmacy.

Sumatriptan

What is Sumatriptan?

Sumatriptan is a migraine treatment that works directly in the brain to ease pain and other symptoms. When taken at the first signs of an attack, it starts working in as little as 15 minutes for the nasal spray, or within 30-60 minutes for the tablets, helping to ease symptoms and stop your migraine from progressing.

At 121doc, we offer Sumatriptan both as a tablet (50 mg, 100 mg) and a nasal spray (20 mg) with a prescription after a short online consultation.

Is Imigram the same as Sumatriptan?

Yes, Imigram and Sumatriptan are the same medicine, since they contain the same active ingredient and work in the same way to treat migraines. Imigram is just the branded version. However, while they are medically-equivalent, they do differ in price, manufacturer, and packaging. Take this into consideration when deciding which is better suited for you.

Why is Sumatriptan restricted?

Sumatriptan is prescribed with care because it requires medical supervision to reduce the risk of serious side effects and harmful drug interactions. In particular, Sumatriptan can negatively affect the cardiovascular system when used too often, increasing the risk of heart attack or stroke.

Another risk with overuse of Sumatriptan is medication overuse headaches. These are persistent headaches caused by taking too much of certain medicines that get worse the more you rely on them. For these reasons, it is important to only take/use it as prescribed by your doctor. In general, your doctor will advise you to take it no more than twice a week.

How does Sumatriptan work?

Sumatriptan belongs to a group of medicines known as triptans, and works by binding to serotonin receptors in the brain, narrowing blood vessels that widen during a migraine attack. This helps stop pain signals being sent to the brain and blocks the release of chemicals that cause inflammation. When taken at the first sign of symptoms, Sumatriptan targets migraines at the source, easing symptoms before they get too bad.

How long does Sumatriptan take to work?

The Sumatriptan nasal spray works in as little as 15 minutes to ease migraine symptoms, whereas the tablets usually take 30-60 minutes. Studies show the effects of Sumatriptan are most strongly felt 2-4 hours after ingestion.

While the nasal spray generally works faster, the effects do not usually last as long as the tablets do. Take this into account when deciding on the method of administration you use.

How effective is Sumatriptan?

Sumatriptan works fast to stop migraines. In one clinical study, over half of patients taking the 50 mg dose were pain-free within 2 hours, and this number rose to 67% with 100 mg. This compares to just 28% of patients taking a placebo.

These results show Sumatriptan’s effectiveness in relieving migraine symptoms, leaving most who take it completely symptom-free.

Who can use Sumatriptan?

To be prescribed Sumatriptan from 121doc, you must be 18-65 years old and diagnosed with migraine.

Do not take Sumatriptan if you have:

  • an allergy to any ingredient found in Sumatriptan
  • a heart problem such as narrowing of the arteries or chest pain (angina)
  • ever had a heart attack
  • circulation problems in your legs that cause pain when you walk (peripheral vascular disease)
  • ever had a stroke or mini-stroke
  • high blood pressure that is not being treated
  • serious liver disease

Additionally, if you are pregnant or breastfeeding, ask your doctor for advice before taking Sumatriptan. Research on the safety of this medication during pregnancy or when breastfeeding is limited, so a doctor will prescribe treatment on a case-by-case basis.

What are the side effects of Sumatriptan?

Sumatriptan can cause side effects you should be aware of, although most are mild and not everybody will get them. Most notably, if you feel temporary muscle spasms in the jaw, or pressure or tightness in the chest or throat, seek immediate medical help. Rarely, these may be signs of a heart attack.

Other common Sumatriptan side effects include:

  • nausea or vomiting
  • tiredness or drowsiness
  • dizziness
  • feeling weak
  • hot flushes
  • temporary increase in blood pressure
  • shortness of breath
  • muscle aches

For a list of all possible side effects, consult the patient information leaflet.

Can you take paracetamol with Sumatriptan?

Yes, you can usually take paracetamol alongside Sumatriptan unless your doctor tells you otherwise, and doing so may help to manage migraine pain more effectively. Just make sure you follow the dosage instructions for each medication and speak with your doctor if you have any concerns.

Can you take Sumatriptan with Ibuprofen?

Yes, ibuprofen is generally safe to take alongside Sumatriptan, but it’s best to check with your doctor first. Taking these medicines together can help some people manage pain more effectively, while for others Sumatriptan alone is enough.

How much Sumatriptan can I take in a day?

The maximum dose of oral Sumatriptan is 3 tablets in any 24-hour period. This makes 300 mg the maximum daily dose, but only if you are prescribed the 100 mg tablets. For the nasal spray, the maximum dose is 40 mg, which equals 2 sprays in total.

Here are some general rules when taking Sumatriptan:

  • If symptoms do not improve after your first dose, do not take a second dose for the same migraine attack.
  • If symptoms do improve, but then return, you can take a second dose after at least 2 hours have passed.
  • With tablets, a third dose may be taken after a further 2 hours if needed. With the nasal spray, do not use more than 2 sprays in 24 hours.

Does Sumatriptan make you sleepy?

Tiredness or drowsiness is listed as a common side effect of Sumatriptan, meaning it affects up to 1 in 10 people who take it. If you respond to treatment in this way, make sure you give yourself time and space to rest after taking it, and do not drive or operate machinery while affected by Sumatriptan.

Can you drink alcohol while on Sumatriptan?

Generally, it is safe to drink alcohol while taking Sumatriptan. However, excessive amounts of alcohol may worsen side effects and can also worsen migraines themselves. Be wary of side effects before you drink during treatment with Sumatriptan and try to only drink in moderation if you do.

Can you buy Sumatriptan over the counter?

No, you cannot get Sumatriptan without a prescription from a licensed healthcare provider. Safety is our number one priority at 121doc, and our doctors will only prescribe treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects

To see if you"re eligible for treatment, all you have to do is complete a short online consultation. Then, if approved by our medical team, your treatment will be delivered direct to your door in discreet packaging.

Medical review byDr. Caroline FontanaLast review 28 January 2026
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Sumatriptan Overview

Type of medicine Triptan
Used for Migraine
Active ingredient Sumatriptan
Works by Narrowing blood vessels in the brain, blocking pain signals and reducing migraine symptoms
Effective within 15-60 minutes, depending on the method of ingestion
Available as Tablets, nasal spray
Available dosage(s) Tablets: 50 mg, 100 mg
Nasal spray: 20 mg
Usage instructions At the onset of migraine symptoms, take 1 tablet or use 1 nasal spray
Packaging Blister packs/nasal spray
Manufacturer Various
Branded available? No

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

Select
Select Select your treatment and complete our online consultation.
Free consultation

Conditions:

Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.

Treatments:

If you know what you want, the quickest way to find a specific medication is to use the search bar here.

Ordering:

Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

Help:

If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe
Prescribe Our doctors review your order.
Free prescription

Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery

Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat
Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off

Repeat:

With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

Save:

There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!