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Fexofenadine

Hay Fever|Active ingredient(s): Fexofenadine hydrochloride|Manufacturer: Various

A woman taking a tablet with a glass of water

Non-drowsy antihistamine for fast-acting hay fever relief

  • Relieves symptoms of hay fever like runny nose, itching, sneezing, watery eyes, and hives
  • Provides fast relief within 1-2 hours, with effects lasting for 24 hours
  • A non-drowsy formula
  • Anti-inflammatory properties help reduce swelling and redness
  • Available as 120 mg tablets

How to use

A woman taking a tablet with a glass of water

Take your tablets

Whichever dose you are prescribed, take 1 tablet at the same time every day with a glass of water

Hand touching the face of an analogue clock

Stay consistent

Fexofenadine works best when taken daily for continuous hay fever support. Take it for as long as you want symptom relief

A woman suffering from hay fever symptoms outside

Avoid triggers

Stay away from things that set off your allergies, like pollen, dust, or certain foods.

What others say about Fexofenadine

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Fexofenadine

What is Fexofenadine used for?

Fexofenadine is an antihistamine, a group of medicines typically used to treat allergies like hay fever (allergic rhinitis). Taken daily, Fexofenadine reduces allergic reactions to things like pollen or dust.

The 120 mg dose is usually given for hay fever, while Fexofenadine 180 mg is prescribed for symptoms of long term allergic skin reactions.

At 121doc, we offer 120 mg Fexofenadine tablets for hay fever with a prescription included after a short online consultation.

How does Fexofenadine work?

Fexofenadine works by binding to histamine receptors (H₁ receptors) to prevent the chemical histamine from causing allergy symptoms like sneezing, runny nose, and watery eyes. In people with hay fever, the immune system overreacts to pollen, especially during warmer months when pollen counts are high. This leads to more histamine being produced by the body, causing symptoms of hay fever to occur.

By blocking histamine from attaching to H₁ receptors, Fexofenadine prevents your immune system from overreacting to pollen, reducing symptoms and easing discomfort.

How effective is Fexofenadine?

Fexofenadine is highly effective as a treatment for hay fever. In one meta analysis involving 12 studies, Fexofenadine delivered significantly greater relief to allergy symptoms compared to a placebo, and was especially effective early in the morning, when hay fever symptoms are often at their worst.

The results also found that Fexofenadine was generally well-tolerated by patients, offering symptom relief without making patients drowsy, and rarely causing other side effects.

How long does Fexofenadine take to work?

Fexofenadine starts working within 1-2 hours after you take it, and lasts for around 24 hours. When taken daily this offers around-the-clock relief from hay fever, so long as you take it at the same time every day. While most often taken seasonally, you can take Fexofenadine for as long as needed to control your allergies, provided your doctor has told you this is okay.

Who can use Fexofenadine?

To be prescribed Fexofenadine or the branded version Telfast from 121doc, you must be over 18 years old and experiencing symptoms of hay fever.

Do not take Fexofenadine if you are:

  • allergic to fexofenadine hydrochloride or any other ingredient in this medicine
  • pregnant
  • breastfeeding

In addition to this, tell your doctor or pharmacist before taking Fexofenadine if you have problems with your liver or kidneys, or you have ever had heart disease. Your doctor will have to determine the safety of treatment on a case-by-case basis.

Does Fexofenadine make you drowsy?

While Fexofenadine can make you drowsy, it is far less likely to have this effect than older hay fever medicines. Fexofenadine (Telfast) is a second-generation antihistamine, a newer type of hay fever treatment that does not cross the brain barrier. This offers allergy control without the sedating effect felt with first-generation antihistamines like Benadryl.

What are the side effects of Fexofenadine?

While Fexofenadine is less likely to make you drowsy than other antihistamines, drowsiness is still listed as a common side effect, meaning it affects up to 1 in 10 people who take it. In addition to this, there are some more possible side effects you should be aware of.

The most common Fexofenadine side effects include:

  • headache
  • nausea (feeling sick)
  • dizziness
  • sleepiness

This is not an exhaustive list. For a full list of Fexofenadine side effects, consult the patient information leaflet.

How much Fexofenadine can I take?

The maximum dose of Fexofenadine is 180 mg per day. This means that the most you can take is 1 tablet per day, no matter which dose you are prescribed. This also applies to Telfast antihistamine tablets.

What should I do if I take too much Fexofenadine?

Taking two hay fever tablets in one day is unlikely to harm you, but it is still important to look out for signs of an overdose. Contact your GP or go to the nearest A&E if you experience headache, a fast heartbeat or drowsiness.

What if I forget to take it?

Missing your scheduled dose by a few hours is fine (if it’s on the same day), but if it’s close to your next dose, skip the missed tablet and take your next one at the usual time. Do not take a double dose to make up for a missed one.

Can I take two Fexofenadine 120 mg tablets if my symptoms are severe?

While unlikely to cause you harm, never take two Fexofenadine tablets unless explicitly instructed by your doctor. Even Fexofenadine 120 mg tablets. Taking too much can cause unpleasant side effects and is unlikely to offer additional hay fever relief.

Is Fexofenadine stronger than Cetirizine?

Both Fexofenadine and Cetirizine are effective hay fever treatments, and one is not necessarily stronger than the other. They do, however, work a little differently, and this may influence your decision on which one to use. Fexofenadine is ideal for people who feel drowsy on antihistamines, as it is less likely to have this side effect, whereas Cetirizine is better suited for people who want quick relief, as it tends to work a little faster.

Can Fexofenadine cause weight gain?

While not listed as a side effect, some scientists believe that antihistamines like Fexofenadine can cause weight gain. This is because of histamine’s effect on appetite and metabolism, as outlined in this study. According to the science, histamine might help slow down or reduce your body’s resistance to leptin (a hormone that controls appetite). Therefore, when histamine is blocked by antihistamines like Fexofenadine, you may find it affects your appetite as well as your hay fever symptoms. However, this has not been definitively proven, and weight differences between patients who take this treatment and those who don’t are negligible.

Can you take Fexofenadine when pregnant?

No, you should not take Fexofenadine when pregnant, unless a doctor deems it necessary. Research into the safety of treatment while pregnant or breastfeeding is limited. Therefore, doctors will generally advise a different treatment unless your symptoms are very severe.

Can I use Fexofenadine tablets with other hay fever relief?

You can use Fexofenadine with some other hay fever treatments, but not all. In general, using a hay fever nasal spray alongside an oral treatment like Fexofenadine is okay. However, using two different oral tablets is usually not safe, and may cause unwanted side effects and even risk an overdose. In any case, ask your doctor before taking two treatments together.

Can you buy Fexofenadine over the counter?

Yes, Fexofenadine is available over the counter, but only the 120 mg dose. The 180 mg dose is prescription-only, and usually only prescribed for hives or if symptoms are severe. Regardless, taking Fexofenadine or Telfast is best done under a doctor’s supervision to ensure safe treatment. Safety is our number one priority at 121doc, and our doctors will only initiate treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects

To see if you’re eligible for treatment, all you have to do is complete a short online consultation. If approved by our medical team, your treatment will be delivered direct to your door in discreet packaging.

Medical review byDr. Caroline FontanaLast review 18 February 2026
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Fexofenadine Overview

Type of medicine Antihistamine
Used for Hay fever symptoms
Active ingredient Fexofenadine hydrochloride
Works by Blocking histamine from binding to H₁ receptors, reducing allergy symptoms
Effective within 1-2 hours
Available as Tablets
Available dosage(s) 120 mg
Usage instructions Take one tablet per day. Take it with water and before a meal.
Packaging Blister packs containing 30 tablets
Manufacturer Various
Branded available? No

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

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  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

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As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

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If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

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Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

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All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

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We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

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All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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