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Treclin Gel

Acne|Active ingredient(s): Clindamycin & Tretinoin|Manufacturer: Various

A woman with skin problems looking at herself in the mirror

Dual-action acne treatment with a soothing gel

  • Combination treatment with both antibiotic (clindamycin) and retinoid (tretinoin)
  • Directly targets the acne-causing bacteria
  • Clears acne fast and prevents new breakouts
  • Soothing gel; applied once daily
  • 1%/0.025% w/w Treclin gel

How to use Treclin gel

A woman washing her face in the sink

Wash your face

Wash your face gently with mild soap and warm water, and dry your skin with a towel.

A hand with a pea-sized amount of gel on the index finger

Apply the gel

Apply a pea-sized amount of Treclin to your face once daily in the evening.

A calendar on a desk with pins stuck into it on specific dates

Use for up to 3 months

Use Treclin gel for the entire course prescribed, but for no longer than 3 months.

What others say about Treclin Gel

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11,238 reviews with score 4.5

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Price is all-inclusive.
Consultation is included.
Prescription is included.

Free shipping.
UK: Free next-day delivery.
Discreet packaging.

Licensed doctors.
Registered pharmacies.
Certified online pharmacy.

Treclin Gel

What is Treclin?

Treclin gel is a topical treatment for acne that directly targets bacteria to clear the skin. When applied daily in the evening, its dual-action formula combines an antibiotic with a retinoid to leave skin healthy and smooth with consistent use. At 121doc, we offer 30 g tubes of Treclin gel containing 1% clindamycin and 0.025% tretinoin.

How does Treclin work?

Treclin gel contains two ingredients to help clear your acne and prevent future breakouts:

  • Clindamycin: an antibiotic that directly targets and kills the bacteria that cause acne. This decreases inflammation and improves skin health.
  • Tretinoin: a retinoid that speeds up skin cell turnover, keeping pores clean and preventing the buildup of dead cells. This improves skin texture and stops acne from breaking out again.

Together, these ingredients address multiple causes of acne, causing your skin to heal quickly and effectively.

How effective is Treclin?

Treclin is a highly effective acne treatment that helps most people significantly reduce their symptoms within weeks.

Clinical data proves this. In one meta-analysis combining three clinical trials, Treclin achieved a 55% reduction in total lesion count after 12 weeks.

Who can use Treclin?

To be prescribed Treclin gel from 121doc, you must be over 18 years old and be approved for treatment in your consultation for acne.

Do not use Treclin if you:

  • are allergic to clindamycin, tretinoin, or any other ingredient found in this product
  • are allergic to lincomycin
  • are pregnant
  • have a chronic inflammatory bowel disease (e.g. Crohn’s or ulcerative colitis)
  • have experienced colitis with past antibiotic use
  • or a family member has ever had skin cancer
  • have rosacea
  • have other acute inflammatory skin conditions (e.g. folliculitis)
  • are treating severe acne characterised by pustular and deep cystic nodular lesions

What are the side effects of Treclin?

Treclin gel may cause some side effects you should be aware of, although not everybody will experience them.

The most common side effects of Treclin are skin reactions such as:

  • dry skin
  • skin photosensitivity
  • itching
  • rash
  • scaling
  • sunburn

This is not an exhaustive list. For a full list of Treclin side effects, consult the patient information leaflet.

How long does Treclin take to work?

Most people notice a reduction in symptoms after a few weeks of using Treclin gel, but it can take up to 12 weeks of consistent use before your skin heals fully. Here is a general timeline of Treclin’s effects:

  • Week 1: you are unlikely to see improvement during this time. In fact, your skin may go through a phase called ‘purging’, where dead cells and bacteria are brought to the surface, making it look and feel worse temporarily.
  • Weeks 2-3: Initial improvements may be seen as your skin begins to heal and repair.
  • Weeks 4-12: Your skin should get better and better during this time, as the ingredients in Treclin kill acne-causing bacteria.

Patience is key to effective acne treatment with Treclin. Make sure you use it for the entire course prescribed or you risk your condition getting worse.

Can you use Treclin long term?

The longest you can use Treclin gel is 12 weeks (3 months). Any longer than this and the risk of skin irritation rises dramatically. Make sure you only take Treclin for the length prescribed by your doctor. Talk with your doctor about alternative acne treatments if you need a more sustainable solution.

Does Treclin help acne scars?

Yes, the tretinoin found in Treclin can help fade the appearance of acne scars by increasing cell turnover and promoting healing. However, Treclin is not prescribed to treat acne scarring, and results are not guaranteed, especially given you can only use Treclin for a maximum of 12 weeks.

Can I get Treclin without a prescription?

No, you cannot get Treclin without a prescription from a licensed healthcare provider. Safety is our number one priority at 121doc, and our doctors will only prescribe treatment if you meet the criteria in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects
Medical review byDr. Caroline FontanaLast review 07 January 2026
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Treclin Gel Overview

Type of medicine Topical acne treatment
Used for Acne
Active ingredient Clindamycin/tretinoin
Works by Killing acne-causing bacteria and promoting skin cell turnover
Effective within 4-12 weeks
Available as Gel
Available dosage(s) Clindamycin 1%/tretinoin 0.025%
Usage instructions Apply a pea-sized amount to the affected area once daily in the evening
Packaging 30 g tube
Manufacturer Various
Generic available? No
Storage instructions Store below 25°C in the original packaging

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

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Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.

Treatments:

If you know what you want, the quickest way to find a specific medication is to use the search bar here.

Ordering:

Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

Help:

If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe
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Free prescription

Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery

Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat
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10 to 15% off

Repeat:

With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

Save:

There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!