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Duac gel

Acne|Active ingredient(s): Benzoyl peroxide & Clindamycin|Manufacturer: Various

A woman looking in a mirror, applying a skin gel to her face

Fast acne relief with a once-daily gel

  • Noticeable improvement in acne symptoms within 2-5 weeks
  • Dual-action formula designed to fight acne at the source
  • Targets acne bacteria and unclogs pores
  • Simple-to-apply once-daily gel
  • Available dosages: 1% clindamycin combined with either 3% or 5% benzoyl peroxide

How to use

Hands being washed under a running tap

Wash your skin

Wash the affected area well and gently pat it dry. Your skin should be completely dry before use

A close-up of a drop of cream on a woman’s finger

Apply the gel

Apply a thin layer of Duac gel to the entire affected area. It should rub easily into your skin

Hand touching the face of an analogue clock

Use once daily

Use Duac once every day in the evening for a maximum of 12 weeks

What others say about Duac gel

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Price is all-inclusive.
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UK: Free next-day delivery.
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Duac gel

What is Duac gel?

Duac Once Daily Gel is a topical acne treatment that targets the skin condition at its source to eliminate symptoms such as blackheads, whiteheads, and inflammation. Applying Duac gel once daily in the evening can help restore your skin to its natural state and prevent future breakouts. It is primarily prescribed to treat mild to moderate acne.

We can prescribe 1%/5% Duac acne gel at 121doc following a successful consultation.

How does Duac gel work?

Duac gel works by killing acne-causing bacteria and unblocking pores. It does this through its two active ingredients:

  • Clindamycin: an antibiotic that kills essential proteins in the acne bacteria to stop it from multiplying.
  • Benzoyl peroxide: releases oxygen to kill acne bacteria, unclogs pores by exfoliating dead skin cells, and reduces inflammation.

This dual-action formula not only kills the bacteria causing your acne, but also exfoliates your skin to leave it smooth and prevent scarring.

How effective is Duac gel?

Duac Gel is highly effective for treating acne, helping most users significantly reduce their symptoms. One study involving 73 patients treated with Duac gel found the following:

  • By week 1: 31.5% of patients saw at least a 30% improvement in non-inflammatory lesions and 39.7% in inflammatory lesions.
  • By week 2: 53.4% of patients saw at least 30% improvement in non-inflammatory lesions and 72.6% in inflammatory lesions.
  • By 12 weeks: Total lesion count was reduced by 69.8%

How long does Duac gel take to work?

Most patients should see some improvement within 2-5 weeks of using Duac acne gel daily. Best results are usually seen by week 12 with consistent use.

How long can I take Duac gel for?

Do not use Duac gel for longer than 12 weeks at a time. Your doctor will instruct you on how long to use it. If it doesn’t work by 12 weeks, speak with your doctor about alternative acne treatments. Using Duac gel for longer than 12 weeks at a time can lead to antibiotic resistance, which is where acne bacteria learns to resist the treatment, making it less effective.

What happens when I stop using Duac gel?

If you use Duac acne treatment for the entire course prescribed, you shouldn’t experience a rebound effect with your skin. However, if the root cause of your acne (e.g. hormones, oil production) hasn’t been addressed, you may gradually see symptoms return. If you experience skin irritation while using Duac gel, this should subside shortly after stopping treatment.

Who can use Duac gel?

To be prescribed Duac gel from 121doc, you must be over 18 years of age and complete a short online consultation, which allows a doctor to ensure the treatment is safe for you.

Do not use Duac gel if you are allergic to any ingredient found in this medicine, or if you are pregnant or breastfeeding. Also, avoid the following:

  • any other acne treatments
  • abrasive soaps and cleansers
  • soaps and cosmetics that have a strong drying effect
  • products containing large amounts of alcohol or astringents
  • using it on broken skin or eczema

How much Duac gel should I use?

Use enough Duac gel to cover the whole area while leaving nothing left on the skin. Once rubbed in, the gel should absorb easily into the skin. Here’s a rough guide detailing how much to use:

  • For your face only: apply one fingertip of Duac gel to the affected area.
  • For your face and back: apply two and a half fingertips to the affected area.

Make sure you cover the entire area affected by acne, not just individual pimples. If the amounts above aren’t enough, you can use a slightly larger amount. If there is some gel still on your skin after rubbing it in, you’ve used too much.

How long do I leave Duac gel on my face?

For the face, apply one fingertip of gel to start with and cover the whole area. This should be enough to absorb into the entire affected area with nothing left over. Apply Duac in the evening and avoid washing your face until the morning to give the gel enough time to fully absorb into the skin.

What are the side effects of Duac gel?

There are some potential side effects associated with Duac gel, but most are mild and temporary. The most common Duac gel side effects include:

  • redness
  • peeling
  • drying
  • headache
  • burning
  • pain
  • sensitivity to sunlight

This is not an exhaustive list. For a full list of Duac gel’s side effects, consult the patient information leaflet.

Can I drink alcohol while using Duac gel?

Yes, it is generally safe to drink alcohol while using Duac Once Daily gel. However, you should be cautious of using skin products containing alcohol, as these may irritate the skin when used on the same area Duac gel is used on and reduce effectiveness.

Is Duac gel a steroid?

No, Duac gel for acne is not a steroid. It is an anti-acne preparation containing an antibiotic (clindamycin) and an antibacterial agent (benzoyl peroxide) that kills acne bacteria at the source and prevents further breakouts. It is, therefore, safe for people who cannot use steroidal acne treatments.

Can I wear makeup over Duac?

Yes, you can wear makeup over Duac gel, but it must be non-greasy, water-based makeup, and should only be applied once Duac has completely dried. Also, ensure Duac is not applied over makeup, as this can interfere with the treatment and cause the acne to worsen.

Can I get Duac gel without a prescription?

No, you cannot get Duac acne gel without a prescription from a licensed healthcare provider. Safety is our top priority at 121doc, and our doctors will only prescribe treatment if you meet the criteria outlined in your online consultation.

A prescription from a trusted healthcare provider like 121doc ensures:

  • safety during treatment
  • effective results
  • monitoring of side effects
Medical review byDr. Caroline FontanaLast review 12 January 2026
Dr. Caroline Fontana

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Duac gel Overview

Type of medicine Antibiotic/antibacterial agent
Used for Acne
Active ingredient Clindamycin & benzoyl peroxide
Works by Stopping acne-causing bacteria from spreading and exfoliating the skin.
Effective within 2-6 weeks
Available as Gel
Available dosage(s) 10 mg/g clindamycin + 50 mg/g benzoyl peroxide
Usage instructions Apply a thin layer to the affected skin once per day
Packaging 30 g tube
Manufacturer Stiefel
Generic available? No
Storage Store below 25°C and discard after 2 months

FAQs

What is included in the online consultation?
Will a doctor review my consultation?
What happens after I submit my order?
What services are included with my order?
Is the price all-inclusive?
What are my delivery options?
Is it safe to buy prescription medication online?
Is this service discreet?
What is included in the online consultation?

Our online consultations are in the format of short medical questionnaires. You will be asked general questions about your health and medical history, as well as specific medical questions relevant to the treatment you have chosen. We will also ask you for your payment and delivery details to complete the order.

Online consultations take no longer than 5 minutes to complete. All questions are necessary when issuing prescription medicines. It means that our doctors can make sure the treatment is safe and right for you.

Will a doctor review my consultation?

Yes, it is a legal requirement that all online consultations are reviewed by a registered doctor. This is to make sure the chosen treatment is safe and right for you to take. All personal information is stored securely and confidentially.

Please note, all orders are subject to doctor approval, and we cannot guarantee that your order will be approved.

What happens after I submit my order?

Your online consultation will be sent directly to our medical team, where it will be reviewed by on of our in-house doctors.

If a doctor approves you for treatment, they will issue a prescription. Your prescription will then be forwarded to our pharmacist, where you medication will be dispensed and dispatched for delivery.

What services are included with my order?

Every order includes:

  • Free consultation - your consultation will be personally reviewed by one of our registered doctors.
  • Free prescription - a doctor will issue you a prescription if approved for treatment.
  • Free delivery - we provide free express delivery across Europe, you should receive your order in 1-2 working days.
Is the price all-inclusive?

Yes, our service is all-inclusive and there are no hidden fees. All 121doc orders include a free online consultation, a free prescription and free express delivery.

What are my delivery options?

We offer several delivery options at no extra charge:

  • Next-day delivery
  • UPS Access Point - convenient parcel drop-off and collection near your home or work address
  • Nominated-day delivery - choose the most convenient day for delivery

All these options can be tracked and require a signature on delivery. If you are not in, a friend or relative can sign in your place.

Is it safe to buy prescription medication online?

It is safe to buy prescription medications online from genuine and reputable healthcare providers, like 121doc.

Our medical staff and facilities are registered with the relevant medical governing bodies. We also ensure your data is protected by adhering to European data privacy laws.

You can learn more about our certifications here.

Is this service discreet?

Our patients’ privacy is of utmost importance. All your medical information is securely stored and only viewed by our doctors. We do not share your details with third-parties. We are also closely adhere to data privacy laws.

All orders will only show on invoices, bank statements, etc. as ‘HHC Ltd’.

How does it work?

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If you know what you want, the quickest way to find a specific medication is to use the search bar here.

Ordering:

Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.

Help:

If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe
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Review:

As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.

Questions:

If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).

Pharmacy:

Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver
Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery

Free:

All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.

Location:

We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).

Discreet:

All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

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Repeat:

With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.

Subscribe:

There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.

Save:

There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!