Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

  • Review by a qualified doctor
  • Including prescription
  • Next-day delivery included

How Prempak C works

Prempak C contains conjugated oestrogen, which aims to replace the natural hormone lost when bodily changes happen as a result of menopause. This loss of oestrogen is what causes most of the bothersome and uncomfortable side effects of menopause.

In addition to replacing natural hormone, it also aims to maintain a healthy womb lining by supplying the body with norgestrel, a natural form of progestogen. Progestogen counteracts the effect of oestrogen on the womb lining. This is required because oestrogen can cause the womb lining to grow uninhibited enhancing the possibility of womb cancer developing.

Who can take Prempak C?

It is prescribed to women who still have a womb and who are experiencing menopause symptoms. You may not have been prescribed this medicine if you are allergic to the hormones in this medication, you have cardiovascular or circulatory issues or you have a history of oestrogen dependent cancers.

Prempak C doses

This medication comes in one dose from 121doc of 1.25mg. The 1.25mg pack comes with 28 yellow tablets each containing 1.25mg of conjugated oestrogens (equine) and 150mcg of norgesterel.

How to use Prempak C

This is an HRT treatment with which you are likely to experience a monthly bleed. This largely has to do with the fact that it contains oestrogen, which needs to be taken at certain points in your cycle.

If you are still menstruating, you should start taking the first tablet on the first day of your period and continue taking the tablets for 16 days. After 16 days the progestogen dose should start and be continued up until day 28 of your cycle. The new pack should then be started straight away.

The side effects

HRT medications carry a risk of side effects, but this doesn't mean that they should be a concern, especially since your doctor will have to monitor you while you use this treatment. Common side effects may include changes in sex drive, feeling bloated, fluid retention, headaches, indigestion, nausea, acne or backache. These shouldn't be lasting and may just be a sign of your body adjusting to your treatment but you should tell your doctor if they are bothering you or you start to notice anything that's worrying you.

Buying treatment online

If you are currently using Prempak C, you may be able to get a repeat prescription online at 121doc, simply complete the online consultation that makes up part of the ordering process. our doctor will then review the information and provide a prescription if they feel that it's safe for you to order online. You will be notified, but your order will automatically be passed to our pharmacy where a pharmacist will dispense your treatment and arrange for it to be shipped, at no additional charge, for next day delivery. Be sure that you have the correct prescription treatment for you, find a range of HRT medications on our HRT treatment page.

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How does it work?

Select Select your treatment


Select a condition here or use the top menu. For every condition, we provide you with information as well as the treatments we currently offer. If you don’t know which is best for you, just click the 'Advise-me' button.


If you know what you want, the quickest way to find a specific medication is to use the search bar here.


Every order starts with an online consultation. We will ask you medical questions to make sure only treatment that is safe and effective is prescribed. We take into account your lifestyle, health and any other medications you’re currently using.

The consultation is completely free, and takes between 5 and 10 minutes of your time.

All your information is safe with us. We don’t share it with anyone unless you want us to.


If you need any guidance, you can call, message or email our customer service team via the ‘How can we help you?' section here.

Prescribe Redeem your prescription


As soon as you place the order, one of our doctors will review your consultation. On working days, this usually takes around one hour.


If the doctor has any additional questions, you will receive a phone call and an email. We understand you might be at work or busy. Our customer service representatives are always discreet and can call back at a more convenient time if necessary.

Our emails never contain any personal or medical information, only a link to your private account on our website (where you will find your messages).


Once our pharmacy receives your prescription, you will get a second email with your package tracking code.

Deliver Expect your delivery the next working day.
Always free. Discreet packaging.
Free next-day delivery


All orders include next-day delivery. Alternatively, you can select a delivery date that suits you better.


We also provide a free UPS Access Point service. Pick up your package from one of many collection points across the UK.

With your tracking code, you will know the estimated delivery time. All we need is your signature (or a friend‘s or relative’s).


All parcels are plainly labelled; there is no logo or any indication of its contents. Inside, you will find your treatment as well as a patient leaflet in your chosen language.

Repeat Subscribe and save with our repeat service. Never miss a dose again.
10 to 15% off


With 121doc’s Subscribe & Save service, you can automatically receive your treatment every few weeks or months.

The order will be generated by us, using the information you provided (including delivery frequency). You don’t have to do anything. Payment is taken two days before shipping.


There are two ways to subscribe. The first is during the order process. The second is via your profile here.

You can cancel or amend your repeat prescriptions at any time.


There are no sign-up fees with this service. Plus, you get a 10% discount off all future prescriptions, increasing to 15% after six orders!